Identifiers | |
---|---|
Symbol | SOBER1 |
InterPro | IPR029058 |
CATH | 6avv |
SCOP2 | 6avv / SCOPe / SUPFAM |
SOBER1 is an enzyme that catalyzes the biochemical reaction of deacetylation. [1] The SOBER (Suppressor of AvrBsT-elicited resistance) 1 protein is conserved in plants and it suppresses the plant's ability to carry out the hypersensitive response against infection by certain pathogenic effector proteins from the YopJ family. [2] SOBER1 belongs to the protein superfamily of α/β hydrolases and possesses a canonical serine/ histidine/ aspartate catalytic triad to carry out the deacetylation reaction. There have been contradicting reports about SOBER1's potential phospholipase activity, with one study claiming phospholipase A2 activity of the protein [3] and another study being unable to reproduce this result. [1]
Members of the SOBER1 family are considered closely related to acyl-protein thioesterases, judged by their protein structure. [2] However, a change in their amino acid sequence renders SOBER1's biochemical properties into a deacetylase; in particular the hydrophobic tunnel, which is found in acyl-protein thioesterases, is impaired by additional amino acids in the lid structure of SOBER1, creating a new surface for binding of the acetyl group. [1]
So far, the following proteins have been identified as SOBER1 targets: AvrBsT; ACIP1.
Identifiers | |
---|---|
Symbol | SOBER1 |
InterPro | IPR029058 |
CATH | 6avv |
SCOP2 | 6avv / SCOPe / SUPFAM |
SOBER1 is an enzyme that catalyzes the biochemical reaction of deacetylation. [1] The SOBER (Suppressor of AvrBsT-elicited resistance) 1 protein is conserved in plants and it suppresses the plant's ability to carry out the hypersensitive response against infection by certain pathogenic effector proteins from the YopJ family. [2] SOBER1 belongs to the protein superfamily of α/β hydrolases and possesses a canonical serine/ histidine/ aspartate catalytic triad to carry out the deacetylation reaction. There have been contradicting reports about SOBER1's potential phospholipase activity, with one study claiming phospholipase A2 activity of the protein [3] and another study being unable to reproduce this result. [1]
Members of the SOBER1 family are considered closely related to acyl-protein thioesterases, judged by their protein structure. [2] However, a change in their amino acid sequence renders SOBER1's biochemical properties into a deacetylase; in particular the hydrophobic tunnel, which is found in acyl-protein thioesterases, is impaired by additional amino acids in the lid structure of SOBER1, creating a new surface for binding of the acetyl group. [1]
So far, the following proteins have been identified as SOBER1 targets: AvrBsT; ACIP1.