(Redirected from
SNX1 (gene))
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| Aliases | SNX1, HsT17379, VPS5, sorting nexin 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601272; MGI: 1928395; HomoloGene: 99716; GeneCards: SNX1; OMA: SNX1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. [5] SNX1 is a component of the retromer complex. [6] [7]
Function
This gene encodes a member of the sorting nexin family. Members of this family contain a phox ( PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members. [8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000028528 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032382 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kurten RC, Cadena DL, Gill GN (May 1996). "Enhanced degradation of EGF receptors by a sorting nexin, SNX1". Science. 272 (5264): 1008–10. Bibcode: 1996Sci...272.1008K. doi: 10.1126/science.272.5264.1008. PMID 8638121. S2CID 42608043.
-
^ Vergés M (2008). Retromer: multipurpose sorting and specialization in polarized transport. International Review of Cell and Molecular Biology. Vol. 271. pp. 153–98.
doi:
10.1016/S1937-6448(08)01204-5.
ISBN
9780123747280.
PMID
19081543.
{{ cite book}}:|journal=ignored ( help) - ^ Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi: 10.1016/j.ceb.2008.03.009. PMC 2833274. PMID 18472259.
- ^ "Entrez Gene: sorting nexin 1".
Further reading
- Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi: 10.1074/jbc.M100606200. PMID 11279102.
- Cozier GE, Carlton J, McGregor AH, et al. (2002). "The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation". J. Biol. Chem. 277 (50): 48730–6. doi: 10.1074/jbc.M206986200. PMID 12198132.
- Shank BB, Wiley HS, Kurten RC (2001). "Structural and functional characterization of the human gene for sorting nexin 1 (SNX1)". DNA Cell Biol. 20 (5): 287–96. doi: 10.1089/104454901750232481. PMID 11410165.
- Liu H, Liu ZQ, Chen CX, et al. (2006). "Inhibitory regulation of EGF receptor degradation by sorting nexin 5". Biochem. Biophys. Res. Commun. 342 (2): 537–46. doi: 10.1016/j.bbrc.2006.01.179. PMID 16487940.
- Bryant DM, Kerr MC, Hammond LA, et al. (2007). "EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin". J. Cell Sci. 120 (Pt 10): 1818–28. doi: 10.1242/jcs.000653. PMID 17502486. S2CID 24175340.
- Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi: 10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
- Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi: 10.1016/S0014-4827(03)00130-7. PMID 12878157.
- Zhong Q, Watson MJ, Lazar CS, et al. (2005). "Determinants of the endosomal localization of sorting nexin 1". Mol. Biol. Cell. 16 (4): 2049–57. doi: 10.1091/mbc.E04-06-0504. PMC 1073682. PMID 15673616.
- Mari M, Bujny MV, Zeuschner D, et al. (2008). "SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors". Traffic. 9 (3): 380–93. doi: 10.1111/j.1600-0854.2007.00686.x. PMID 18088323. S2CID 31922423.
- Nguyen LN, Holdren MS, Nguyen AP, et al. (2006). "Sorting nexin 1 down-regulation promotes colon tumorigenesis". Clin. Cancer Res. 12 (23): 6952–9. doi: 10.1158/1078-0432.CCR-06-0317. hdl: 11336/31768. PMID 17145813.
- Pons V, Hullin-Matsuda F, Nauze M, et al. (2003). "Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor". J. Biol. Chem. 278 (23): 21155–61. doi: 10.1074/jbc.M211008200. PMID 12657642.
- Rojas R, Kametaka S, Haft CR, Bonifacino JS (2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors". Mol. Cell. Biol. 27 (3): 1112–24. doi: 10.1128/MCB.00156-06. PMC 1800681. PMID 17101778.
- Gullapalli A, Wolfe BL, Griffin CT, et al. (2006). "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins". Mol. Biol. Cell. 17 (3): 1228–38. doi: 10.1091/mbc.E05-09-0899. PMC 1382312. PMID 16407403.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Zhong Q, Lazar CS, Tronchère H, et al. (2002). "Endosomal localization and function of sorting nexin 1". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6767–72. Bibcode: 2002PNAS...99.6767Z. doi: 10.1073/pnas.092142699. PMC 124477. PMID 11997453.
- Wang Y, Zhou Y, Szabo K, et al. (2002). "Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1". Mol. Biol. Cell. 13 (6): 1965–76. doi: 10.1091/mbc.E01-11-0131. PMC 117618. PMID 12058063.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Carlton J, Bujny M, Peter BJ, et al. (2004). "Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides". Curr. Biol. 14 (20): 1791–800. doi: 10.1016/j.cub.2004.09.077. hdl: 1874/12362. PMID 15498486. S2CID 10366991.
- Kurten RC, Eddington AD, Chowdhury P, et al. (2001). "Self-assembly and binding of a sorting nexin to sorting endosomes". J. Cell Sci. 114 (Pt 9): 1743–56. doi: 10.1242/jcs.114.9.1743. PMID 11309204.
External links
- sorting+nexins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it. |
(Redirected from
SNX1 (gene))
| SNX1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | SNX1, HsT17379, VPS5, sorting nexin 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601272; MGI: 1928395; HomoloGene: 99716; GeneCards: SNX1; OMA: SNX1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. [5] SNX1 is a component of the retromer complex. [6] [7]
Function
This gene encodes a member of the sorting nexin family. Members of this family contain a phox ( PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members. [8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000028528 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032382 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kurten RC, Cadena DL, Gill GN (May 1996). "Enhanced degradation of EGF receptors by a sorting nexin, SNX1". Science. 272 (5264): 1008–10. Bibcode: 1996Sci...272.1008K. doi: 10.1126/science.272.5264.1008. PMID 8638121. S2CID 42608043.
-
^ Vergés M (2008). Retromer: multipurpose sorting and specialization in polarized transport. International Review of Cell and Molecular Biology. Vol. 271. pp. 153–98.
doi:
10.1016/S1937-6448(08)01204-5.
ISBN
9780123747280.
PMID
19081543.
{{ cite book}}:|journal=ignored ( help) - ^ Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi: 10.1016/j.ceb.2008.03.009. PMC 2833274. PMID 18472259.
- ^ "Entrez Gene: sorting nexin 1".
Further reading
- Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi: 10.1074/jbc.M100606200. PMID 11279102.
- Cozier GE, Carlton J, McGregor AH, et al. (2002). "The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation". J. Biol. Chem. 277 (50): 48730–6. doi: 10.1074/jbc.M206986200. PMID 12198132.
- Shank BB, Wiley HS, Kurten RC (2001). "Structural and functional characterization of the human gene for sorting nexin 1 (SNX1)". DNA Cell Biol. 20 (5): 287–96. doi: 10.1089/104454901750232481. PMID 11410165.
- Liu H, Liu ZQ, Chen CX, et al. (2006). "Inhibitory regulation of EGF receptor degradation by sorting nexin 5". Biochem. Biophys. Res. Commun. 342 (2): 537–46. doi: 10.1016/j.bbrc.2006.01.179. PMID 16487940.
- Bryant DM, Kerr MC, Hammond LA, et al. (2007). "EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin". J. Cell Sci. 120 (Pt 10): 1818–28. doi: 10.1242/jcs.000653. PMID 17502486. S2CID 24175340.
- Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi: 10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
- Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi: 10.1016/S0014-4827(03)00130-7. PMID 12878157.
- Zhong Q, Watson MJ, Lazar CS, et al. (2005). "Determinants of the endosomal localization of sorting nexin 1". Mol. Biol. Cell. 16 (4): 2049–57. doi: 10.1091/mbc.E04-06-0504. PMC 1073682. PMID 15673616.
- Mari M, Bujny MV, Zeuschner D, et al. (2008). "SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors". Traffic. 9 (3): 380–93. doi: 10.1111/j.1600-0854.2007.00686.x. PMID 18088323. S2CID 31922423.
- Nguyen LN, Holdren MS, Nguyen AP, et al. (2006). "Sorting nexin 1 down-regulation promotes colon tumorigenesis". Clin. Cancer Res. 12 (23): 6952–9. doi: 10.1158/1078-0432.CCR-06-0317. hdl: 11336/31768. PMID 17145813.
- Pons V, Hullin-Matsuda F, Nauze M, et al. (2003). "Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor". J. Biol. Chem. 278 (23): 21155–61. doi: 10.1074/jbc.M211008200. PMID 12657642.
- Rojas R, Kametaka S, Haft CR, Bonifacino JS (2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors". Mol. Cell. Biol. 27 (3): 1112–24. doi: 10.1128/MCB.00156-06. PMC 1800681. PMID 17101778.
- Gullapalli A, Wolfe BL, Griffin CT, et al. (2006). "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins". Mol. Biol. Cell. 17 (3): 1228–38. doi: 10.1091/mbc.E05-09-0899. PMC 1382312. PMID 16407403.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Zhong Q, Lazar CS, Tronchère H, et al. (2002). "Endosomal localization and function of sorting nexin 1". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6767–72. Bibcode: 2002PNAS...99.6767Z. doi: 10.1073/pnas.092142699. PMC 124477. PMID 11997453.
- Wang Y, Zhou Y, Szabo K, et al. (2002). "Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1". Mol. Biol. Cell. 13 (6): 1965–76. doi: 10.1091/mbc.E01-11-0131. PMC 117618. PMID 12058063.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Carlton J, Bujny M, Peter BJ, et al. (2004). "Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides". Curr. Biol. 14 (20): 1791–800. doi: 10.1016/j.cub.2004.09.077. hdl: 1874/12362. PMID 15498486. S2CID 10366991.
- Kurten RC, Eddington AD, Chowdhury P, et al. (2001). "Self-assembly and binding of a sorting nexin to sorting endosomes". J. Cell Sci. 114 (Pt 9): 1743–56. doi: 10.1242/jcs.114.9.1743. PMID 11309204.
External links
- sorting+nexins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
| This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it. |