Sorting nexin-15 is a
protein that in humans is encoded by the SNX15gene.[4][5]
This gene encodes a member of the
sorting nexin family. Members of this family contain a
phox (PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular trafficking.
Overexpression of this gene results in a decrease in the processing of
insulin and
hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of
furin, the
endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in
endosomal trafficking from the
plasma membranee to recycling
endosomes or the
trans-Golgi network. This gene encodes two transcript variants encoding distinct
isoforms.[5]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Barr VA, Phillips SA, Taylor SI, Haft CR (Mar 2001). "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking". Traffic. 1 (11): 904–16.
doi:
10.1034/j.1600-0854.2000.011109.x.
PMID11208079.
S2CID31092568.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Sorting nexin-15 is a
protein that in humans is encoded by the SNX15gene.[4][5]
This gene encodes a member of the
sorting nexin family. Members of this family contain a
phox (PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular trafficking.
Overexpression of this gene results in a decrease in the processing of
insulin and
hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of
furin, the
endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in
endosomal trafficking from the
plasma membranee to recycling
endosomes or the
trans-Golgi network. This gene encodes two transcript variants encoding distinct
isoforms.[5]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Barr VA, Phillips SA, Taylor SI, Haft CR (Mar 2001). "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking". Traffic. 1 (11): 904–16.
doi:
10.1034/j.1600-0854.2000.011109.x.
PMID11208079.
S2CID31092568.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.