From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Neutral Sphingomyelinase2 is an
enzyme that in humans is encoded by the SMPD3
gene.
[5]
[6]
References
Further reading
- Chagnon P, Michaud J, Mitchell G, et al. (2003).
"A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9.
doi:
10.1086/344580.
PMC
378590.
PMID
12417987.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Marchesini N, Luberto C, Hannun YA (2003).
"Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism". J. Biol. Chem. 278 (16): 13775–83.
doi:
10.1074/jbc.M212262200.
PMID
12566438.
- Miura Y, Gotoh E, Nara F, et al. (2004).
"Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases". FEBS Lett. 557 (1–3): 288–92.
doi:
10.1016/S0014-5793(03)01523-0.
PMID
14741383.
S2CID
34738077.
- Marchesini N, Osta W, Bielawski J, et al. (2004).
"Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells". J. Biol. Chem. 279 (24): 25101–11.
doi:
10.1074/jbc.M313662200.
PMID
15051724.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Jana A, Pahan K (2005).
"Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase". J. Neurosci. 24 (43): 9531–40.
doi:
10.1523/JNEUROSCI.3085-04.2004.
PMC
1955476.
PMID
15509740.
- Krut O, Wiegmann K, Kashkar H, et al. (2006).
"Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein". J. Biol. Chem. 281 (19): 13784–93.
doi:
10.1074/jbc.M511306200.
PMID
16517606.
- Levy M, Castillo SS, Goldkorn T (2006).
"nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis". Biochem. Biophys. Res. Commun. 344 (3): 900–5.
doi:
10.1016/j.bbrc.2006.04.013.
PMC
4370275.
PMID
16631623.
- Clarke CJ, Truong TG, Hannun YA (2007).
"Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2". J. Biol. Chem. 282 (2): 1384–96.
doi:
10.1074/jbc.M609216200.
PMID
17085432.
- Tani M, Hannun YA (2007).
"Analysis of membrane topology of neutral sphingomyelinase 2". FEBS Lett. 581 (7): 1323–8.
doi:
10.1016/j.febslet.2007.02.046.
PMC
1868537.
PMID
17349629.
- Filosto S, Fry W, Knowlton A, Goldkorn T (2010).
"Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)". J. Biol. Chem. 285 (14): 10213–22.
doi:
10.1074/jbc.M109.069963.
PMC
2856226.
PMID
20106976.