From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Protein SET , also known as Protein SET 1 , is a
protein that in humans is encoded by the SET
gene .
[5]
[6]
[7]
Interactions
Protein SET has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000119335 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000054766 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992).
"Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene" . Molecular and Cellular Biology . 12 (8): 3346–55.
doi :
10.1128/mcb.12.8.3346 .
PMC
364582 .
PMID
1630450 .
^ Li M, Makkinje A, Damuni Z (May 1996).
"The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A" . The Journal of Biological Chemistry . 271 (19): 11059–62.
doi :
10.1074/jbc.271.19.11059 .
PMID
8626647 .
^
"Entrez Gene: SET SET translocation (myeloid leukemia-associated)" .
^
a
b Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001).
"Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein" . Cell . 104 (1): 119–30.
doi :
10.1016/s0092-8674(01)00196-9 .
PMID
11163245 .
S2CID
11144887 .
^ Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002).
"HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A" . Molecular and Cellular Biology . 22 (8): 2810–20.
doi :
10.1128/mcb.22.8.2810-2820.2002 .
PMC
133744 .
PMID
11909973 .
^ Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002).
"The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity" . The Journal of Biological Chemistry . 277 (9): 7324–32.
doi :
10.1074/jbc.M107270200 .
hdl :
10536/DRO/DU:30101408 .
PMID
11741927 .
^ Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003).
"Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain" . Molecular and Cellular Biology . 23 (23): 8528–41.
doi :
10.1128/mcb.23.23.8528-8541.2003 .
PMC
262669 .
PMID
14612398 .
^ Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003).
"Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor" . Cell . 112 (5): 659–72.
doi :
10.1016/s0092-8674(03)00150-8 .
PMID
12628186 .
S2CID
14019153 .
Further reading
Nagata K, Kawase H, Handa H, Yano K, Yamasaki M, Ishimi Y, Okuda A, Kikuchi A, Matsumoto K (May 1995).
"Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis" . Proceedings of the National Academy of Sciences of the United States of America . 92 (10): 4279–83.
Bibcode :
1995PNAS...92.4279N .
doi :
10.1073/pnas.92.10.4279 .
PMC
41927 .
PMID
7753797 .
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Adachi Y, Pavlakis GN, Copeland TD (Mar 1994).
"Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia" . FEBS Letters . 340 (3): 231–5.
Bibcode :
1994FEBSL.340..231A .
doi :
10.1016/0014-5793(94)80144-4 .
PMID
8131851 .
S2CID
36974869 .
Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B, Kratzin HD, Hilschmann N (Feb 1994). "Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII". Biological Chemistry Hoppe-Seyler . 375 (2): 113–26.
doi :
10.1515/bchm3.1994.375.2.113 .
PMID
8192856 .
Adachi Y, Pavlakis GN, Copeland TD (Jan 1994).
"Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia" . The Journal of Biological Chemistry . 269 (3): 2258–62.
doi :
10.1016/S0021-9258(17)42162-4 .
PMID
8294483 .
Adler HT, Nallaseth FS, Walter G, Tkachuk DC (Nov 1997).
"HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A" . The Journal of Biological Chemistry . 272 (45): 28407–14.
doi :
10.1074/jbc.272.45.28407 .
PMID
9353299 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Carlson SG, Eng E, Kim EG, Perlman EJ, Copeland TD, Ballermann BJ (Oct 1998).
"Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor" . Journal of the American Society of Nephrology . 9 (10): 1873–80.
doi :
10.1681/ASN.V9101873 .
PMID
9773788 .
Brennan CM, Gallouzi IE, Steitz JA (Oct 2000).
"Protein ligands to HuR modulate its interaction with target mRNAs in vivo" . The Journal of Cell Biology . 151 (1): 1–14.
doi :
10.1083/jcb.151.1.1 .
PMC
2189805 .
PMID
11018049 .
Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB (Dec 2000).
"Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators" . Molecular and Cellular Biology . 20 (23): 8933–43.
doi :
10.1128/MCB.20.23.8933-8943.2000 .
PMC
86548 .
PMID
11073993 .
Hartley JL, Temple GF, Brasch MA (Nov 2000).
"DNA cloning using in vitro site-specific recombination" . Genome Research . 10 (11): 1788–95.
doi :
10.1101/gr.143000 .
PMC
310948 .
PMID
11076863 .
Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001).
"Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein" . Cell . 104 (1): 119–30.
doi :
10.1016/S0092-8674(01)00196-9 .
PMID
11163245 .
S2CID
11144887 .
Minakuchi M, Kakazu N, Gorrin-Rivas MJ, Abe T, Copeland TD, Ueda K, Adachi Y (Mar 2001).
"Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET" (PDF) . European Journal of Biochemistry . 268 (5): 1340–51.
doi :
10.1046/j.1432-1327.2001.02000.x .
hdl :
2433/150179 .
PMID
11231286 .
Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J (Nov 2001).
"Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks" . The Journal of Biological Chemistry . 276 (46): 43285–93.
doi :
10.1074/jbc.M108137200 .
PMID
11555662 .
Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002).
"The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity" . The Journal of Biological Chemistry . 277 (9): 7324–32.
doi :
10.1074/jbc.M107270200 .
hdl :
10536/DRO/DU:30101408 .
PMID
11741927 .
Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002).
"HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A" . Molecular and Cellular Biology . 22 (8): 2810–20.
doi :
10.1128/MCB.22.8.2810-2820.2002 .
PMC
133744 .
PMID
11909973 .
Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M (Jul 2002).
"The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing" . The Journal of Biological Chemistry . 277 (28): 25026–31.
doi :
10.1074/jbc.M202256200 .
PMID
11978794 .