From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a
chaperone protein that in humans is encoded by the RIC3
gene . The RIC3 gene was first discovered in
C. elegans .
[5] RIC-3 protein is conserved in most animals and influences the maturation of various
ligand gated ion channels including the
serotonin
5-HT3 receptor and
nicotinic acetylcholine receptors ,
[6]
[7] particularly the
homomeric
α7 nicotinic receptor . RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000166405 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000048330 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nguyen M, Alfonso A, Johnson CD, Rand JB (Jun 1995).
"Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase" . Genetics . 140 (2): 527–35.
doi :
10.1093/genetics/140.2.527 .
PMC
1206632 .
PMID
7498734 .
^ Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M (Sep 2003).
"Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression" . J Biol Chem . 278 (36): 34411–7.
doi :
10.1074/jbc.M300170200 .
hdl :
10261/289220 .
PMID
12821669 .
^
"Entrez Gene: RIC3 resistance to inhibitors of cholinesterase 3 homolog (C. elegans)" .
^ Williams ME, Burton B, Urrutia A, et al. (2005).
"Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells" . J. Biol. Chem . 280 (2): 1257–63.
doi :
10.1074/jbc.M410039200 .
PMID
15504725 .
Further reading
Cheng A, Bollan KA, Greenwood SM, et al. (2007).
"Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition" . J. Biol. Chem . 282 (36): 26158–66.
doi :
10.1074/jbc.M703899200 .
PMID
17609200 .
Castillo M, Mulet J, Gutiérrez LM, et al. (2007). "Role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors". J. Mol. Neurosci . 30 (1–2): 153–6.
doi :
10.1385/JMN:30:1:153 .
PMID
17192664 .
S2CID
41109579 .
Lansdell SJ, Gee VJ, Harkness PC, et al. (2005). "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells". Mol. Pharmacol . 68 (5): 1431–8.
doi :
10.1124/mol.105.017459 .
PMID
16120769 .
S2CID
12901942 .
Castillo M, Mulet J, Gutiérrez LM, et al. (2005).
"Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors" . J. Biol. Chem . 280 (29): 27062–8.
doi :
10.1074/jbc.M503746200 .
hdl :
10261/307538 .
PMID
15927954 .
Cheng A, McDonald NA, Connolly CN (2005).
"Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3" . J. Biol. Chem . 280 (23): 22502–7.
doi :
10.1074/jbc.M414341200 .
PMID
15809299 .
Bennett HM, Lees K, et al. (2012).
"Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes" . J. Neurochem . 123 (6): 911–8.
doi :
10.1111/jnc.12013 .
PMC
3549563 .
PMID
22970690 .
Koperniak TM, Garg BK, et al. (2013).
"Cell-specific effects on surface α7 nicotinic receptor expression revealed by over-expression and knockdown of rat RIC3 protein" . J. Neurochem . 124 (3): 300–9.
doi :
10.1111/jnc.12095 .
PMID
23157401 .
S2CID
12489865 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Clark HF, Gurney AL, Abaya E, et al. (2003).
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .