RNA-binding motif protein, Y chromosome, family 1 member A1/C is a
protein that in humans is encoded by the RBMY1A1gene.[3][4][5]
This gene encodes a protein containing an RNA-binding motif in the
N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the
C-terminus. Multiple copies of this gene are found in the AZFb
azoospermia factor region of
chromosome Y and the encoded protein is thought to be involved in
spermatogenesis. Most copies of this locus are
pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked.
Alternative splicing of transcripts results in two transcript variants that encode different proteins.[5]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ma K, Inglis JD, Sharkey A, Bickmore WA, Hill RE, Prosser EJ, Speed RM, Thomson EJ, Jobling M, Taylor K, et al. (Jan 1994). "A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis". Cell. 75 (7): 1287–95.
doi:
10.1016/0092-8674(93)90616-X.
PMID8269511.
S2CID24678568.
^Chai NN, Zhou H, Hernandez J, Najmabadi H, Bhasin S, Yen PH (Aug 1998). "Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene". Genomics. 49 (2): 283–9.
doi:
10.1006/geno.1998.5255.
PMID9598316.
Lavery R, Glennon M, Houghton J, et al. (2007). "Investigation of DAZ and RBMY1 gene expression in human testis by quantitative real-time PCR". Arch. Androl. 53 (2): 71–3.
doi:
10.1080/01485010600915228.
PMID17453684.
S2CID22899385.
Tsuei DJ, Hsu HC, Lee PH, et al. (2004). "RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts". Oncogene. 23 (34): 5815–22.
doi:
10.1038/sj.onc.1207773.
PMID15184870.
S2CID20055243.
Tsuei DJ,
Chang MH,
Chen PJ, et al. (2003). "Characterization of integration patterns and flanking cellular sequences of hepatitis B virus in childhood hepatocellular carcinomas". J. Med. Virol. 68 (4): 513–21.
doi:
10.1002/jmv.10240.
PMID12376959.
S2CID26869562.
Elliott DJ, Oghene K, Makarov G, et al. (1998). "Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell development". J. Cell Sci. 111 (9): 1255–65.
doi:
10.1242/jcs.111.9.1255.
PMID9547301.
Prosser J, Inglis JD, Condie A, et al. (1997). "Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene". Mamm. Genome. 7 (11): 835–42.
doi:
10.1007/s003359900246.
PMID8875892.
S2CID23907707.
RNA-binding motif protein, Y chromosome, family 1 member A1/C is a
protein that in humans is encoded by the RBMY1A1gene.[3][4][5]
This gene encodes a protein containing an RNA-binding motif in the
N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the
C-terminus. Multiple copies of this gene are found in the AZFb
azoospermia factor region of
chromosome Y and the encoded protein is thought to be involved in
spermatogenesis. Most copies of this locus are
pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked.
Alternative splicing of transcripts results in two transcript variants that encode different proteins.[5]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ma K, Inglis JD, Sharkey A, Bickmore WA, Hill RE, Prosser EJ, Speed RM, Thomson EJ, Jobling M, Taylor K, et al. (Jan 1994). "A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis". Cell. 75 (7): 1287–95.
doi:
10.1016/0092-8674(93)90616-X.
PMID8269511.
S2CID24678568.
^Chai NN, Zhou H, Hernandez J, Najmabadi H, Bhasin S, Yen PH (Aug 1998). "Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene". Genomics. 49 (2): 283–9.
doi:
10.1006/geno.1998.5255.
PMID9598316.
Lavery R, Glennon M, Houghton J, et al. (2007). "Investigation of DAZ and RBMY1 gene expression in human testis by quantitative real-time PCR". Arch. Androl. 53 (2): 71–3.
doi:
10.1080/01485010600915228.
PMID17453684.
S2CID22899385.
Tsuei DJ, Hsu HC, Lee PH, et al. (2004). "RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts". Oncogene. 23 (34): 5815–22.
doi:
10.1038/sj.onc.1207773.
PMID15184870.
S2CID20055243.
Tsuei DJ,
Chang MH,
Chen PJ, et al. (2003). "Characterization of integration patterns and flanking cellular sequences of hepatitis B virus in childhood hepatocellular carcinomas". J. Med. Virol. 68 (4): 513–21.
doi:
10.1002/jmv.10240.
PMID12376959.
S2CID26869562.
Elliott DJ, Oghene K, Makarov G, et al. (1998). "Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell development". J. Cell Sci. 111 (9): 1255–65.
doi:
10.1242/jcs.111.9.1255.
PMID9547301.
Prosser J, Inglis JD, Condie A, et al. (1997). "Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene". Mamm. Genome. 7 (11): 835–42.
doi:
10.1007/s003359900246.
PMID8875892.
S2CID23907707.