Chang Mei-hwei ( Chinese: 張美惠; born 1949) is a Taiwanese pediatric hepatologist.

Chang graduated from the National Taiwan University College of Medicine, ^[1] completed fellowship training in pediatric gastroenterology at UCLA Health, ^{[2] [3]} and later returned to Taiwan, subsequently serving as a distinguished chair professor within NTU's Department of Pediatrics. ^[1] Chang has researched hepatitis B vaccination, ^[4] biliary atresia in infants, ^[5] and led the Children's Liver Foundation. ^{[6] [7]} She was featured in the 2016 documentary Taiwan Revealed: Medical Elite. ^[8]

In 2013, Chang was awarded the TWAS Prize in Medical Science. ^{[9] [10]} The following year, she was elected an academician of Academia Sinica. ^[11] Chang was elected to fellowship within The World Academy of Sciences in 2018. ^{[12] [13]}