Clinical data | |
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Trade names | Permitabs, [1] others |
Routes of administration | Topical |
ATC code | |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
Chemical and physical data | |
Formula | KMnO4 |
Molar mass | 158.032 |
3D model ( JSmol) | |
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Potassium permanganate is used as a medication for a number of skin conditions. [2] This includes fungal infections of the foot, impetigo, pemphigus, superficial wounds, dermatitis, and tropical ulcers. [3] [2] For tropical ulcers it is used together with procaine benzylpenicillin. [2] Typically it is used in skin conditions that produce a lot of liquid. [3] It can be applied as a soaked dressing or a bath. [2]
Side effects may include irritation of the skin and discoloration of clothing. [2] If it is taken by mouth, toxicity and death may occur. [4] Potassium permanganate is an oxidizing agent. [5] The British National Formulary recommends that each 100 mg be dissolved in a liter of water before use. [3]
Potassium permanganate was first made in the 1600s and came into common medical use at least as early as the 1800s. [6] It is on the World Health Organization's List of Essential Medicines. [7]
Uses include for fungal infections of the foot, impetigo, pemphigus, superficial wounds, dermatitis (eczema), and tropical ulcers. [3] [2] Typically it is used in skin conditions that produce a lot of liquid. [3] For tropical ulcers it is used together with procaine benzylpenicillin for two to four weeks. [2] [8]
It can be used in children and adults. [8] It can be applied as a soaked dressing or a bath. [2] Petroleum jelly may be used on the nails before soaking to prevent their discoloration. [1] The U.S. Food and Drug Administration does not recommend its use in either the crystal or tablet form. [9]
Side effects may include irritation of the skin and discoloration of clothing. [2] A harsh burn on a child from an undissolved tablet has been reported. [10] For treating eczema, it is recommended using for a few days at a time due to the possibility of it irritating the skin. [10] Higher concentration solutions can result in chemical burns. [11] Therefore, the British National Formulary recommends 100 mg be dissolved in a liter of water before use to form a 1:10,000 (0.01%) solution. [3] [10] Wrapping the dressings soaked with potassium permanganate is not recommended. [8]
If taken by mouth it is toxic. [12] Side effects may include nausea, vomiting, and shortness of breath may occur. [13] If a sufficiently large amount (about 10 grams) is eaten death may occur. [4] [13]
Concentrated solutions when drunk have resulted in Acute Respiratory Distress Syndrome or swelling of the airway. [14] Recommended measures for those who have ingested potassium permanganate include gastroscopy. [14] Activated charcoal or medications to cause vomiting are not recommended. [14] While medications like ranitidine and N-acetylcysteine may be used in toxicity, evidence for this use is poor. [14]
Potassium permanganate functions as an oxidising agent. [15] Through this mechanism it results in disinfection, astringent effects, and decreased smell. [15]
Potassium permanganate was first made in the 1600s and came into common medical use at least as early as the 1800s. [6] During World War I Canadian soldiers were given potassium permanganate (to be applied mixed with an ointment) in an effort to prevent sexually transmitted infections (resulting mostly in violet stained genitals.) [16] Some have attempted to bring about an abortion by putting it in the vagina, though this is not effective. [17] [18] [19] Other historical uses have included as an effort to wash out the stomach in those with strychnine or picrotoxin poisoning. [20]
In the United States the FDA requires tablets of the medication to be sold by prescription. [9] Potassium permanganate, however, does not have FDA approved uses and therefore non medical grade potassium permanganate is sometimes used for medical use.[ citation needed]
It is available under a number of brand names including Permasol, Koi Med Tricho-Ex, and Kalii permanganas RFF. [21] It is occasionally called "Condy's crystals". [15]
Potassium permanganate may be used to prevent the spread of glanders among horses. [22]
Clinical data | |
---|---|
Trade names | Permitabs, [1] others |
Routes of administration | Topical |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
Chemical and physical data | |
Formula | KMnO4 |
Molar mass | 158.032 |
3D model ( JSmol) | |
| |
|
Potassium permanganate is used as a medication for a number of skin conditions. [2] This includes fungal infections of the foot, impetigo, pemphigus, superficial wounds, dermatitis, and tropical ulcers. [3] [2] For tropical ulcers it is used together with procaine benzylpenicillin. [2] Typically it is used in skin conditions that produce a lot of liquid. [3] It can be applied as a soaked dressing or a bath. [2]
Side effects may include irritation of the skin and discoloration of clothing. [2] If it is taken by mouth, toxicity and death may occur. [4] Potassium permanganate is an oxidizing agent. [5] The British National Formulary recommends that each 100 mg be dissolved in a liter of water before use. [3]
Potassium permanganate was first made in the 1600s and came into common medical use at least as early as the 1800s. [6] It is on the World Health Organization's List of Essential Medicines. [7]
Uses include for fungal infections of the foot, impetigo, pemphigus, superficial wounds, dermatitis (eczema), and tropical ulcers. [3] [2] Typically it is used in skin conditions that produce a lot of liquid. [3] For tropical ulcers it is used together with procaine benzylpenicillin for two to four weeks. [2] [8]
It can be used in children and adults. [8] It can be applied as a soaked dressing or a bath. [2] Petroleum jelly may be used on the nails before soaking to prevent their discoloration. [1] The U.S. Food and Drug Administration does not recommend its use in either the crystal or tablet form. [9]
Side effects may include irritation of the skin and discoloration of clothing. [2] A harsh burn on a child from an undissolved tablet has been reported. [10] For treating eczema, it is recommended using for a few days at a time due to the possibility of it irritating the skin. [10] Higher concentration solutions can result in chemical burns. [11] Therefore, the British National Formulary recommends 100 mg be dissolved in a liter of water before use to form a 1:10,000 (0.01%) solution. [3] [10] Wrapping the dressings soaked with potassium permanganate is not recommended. [8]
If taken by mouth it is toxic. [12] Side effects may include nausea, vomiting, and shortness of breath may occur. [13] If a sufficiently large amount (about 10 grams) is eaten death may occur. [4] [13]
Concentrated solutions when drunk have resulted in Acute Respiratory Distress Syndrome or swelling of the airway. [14] Recommended measures for those who have ingested potassium permanganate include gastroscopy. [14] Activated charcoal or medications to cause vomiting are not recommended. [14] While medications like ranitidine and N-acetylcysteine may be used in toxicity, evidence for this use is poor. [14]
Potassium permanganate functions as an oxidising agent. [15] Through this mechanism it results in disinfection, astringent effects, and decreased smell. [15]
Potassium permanganate was first made in the 1600s and came into common medical use at least as early as the 1800s. [6] During World War I Canadian soldiers were given potassium permanganate (to be applied mixed with an ointment) in an effort to prevent sexually transmitted infections (resulting mostly in violet stained genitals.) [16] Some have attempted to bring about an abortion by putting it in the vagina, though this is not effective. [17] [18] [19] Other historical uses have included as an effort to wash out the stomach in those with strychnine or picrotoxin poisoning. [20]
In the United States the FDA requires tablets of the medication to be sold by prescription. [9] Potassium permanganate, however, does not have FDA approved uses and therefore non medical grade potassium permanganate is sometimes used for medical use.[ citation needed]
It is available under a number of brand names including Permasol, Koi Med Tricho-Ex, and Kalii permanganas RFF. [21] It is occasionally called "Condy's crystals". [15]
Potassium permanganate may be used to prevent the spread of glanders among horses. [22]