Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is an
enzyme that in humans is encoded by the NUDT21gene.[5][6] It belongs to the
Nudix family of hydrolases.
The protein encoded by this gene is one subunit of the
cleavage factor Im complex required for 3' RNA cleavage and polyadenylation processing.[7] The interaction of the protein with the
RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides.[6]
Kim H, Lee Y (2002). "Interaction of poly(A) polymerase with the 25-kDa subunit of cleavage factor I". Biochem. Biophys. Res. Commun. 289 (2): 513–8.
doi:
10.1006/bbrc.2001.5992.
PMID11716503.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105.
doi:
10.1038/ncb1086.
PMID14743216.
S2CID11683986.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101.
doi:
10.1038/nbt1046.
PMID15592455.
S2CID7200157.
Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is an
enzyme that in humans is encoded by the NUDT21gene.[5][6] It belongs to the
Nudix family of hydrolases.
The protein encoded by this gene is one subunit of the
cleavage factor Im complex required for 3' RNA cleavage and polyadenylation processing.[7] The interaction of the protein with the
RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides.[6]
Kim H, Lee Y (2002). "Interaction of poly(A) polymerase with the 25-kDa subunit of cleavage factor I". Biochem. Biophys. Res. Commun. 289 (2): 513–8.
doi:
10.1006/bbrc.2001.5992.
PMID11716503.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105.
doi:
10.1038/ncb1086.
PMID14743216.
S2CID11683986.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101.
doi:
10.1038/nbt1046.
PMID15592455.
S2CID7200157.