From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
NPW is a
gene that in humans encodes
Neuropeptide W
protein .
[5]
[6]
[7]
Neuropeptide W (NPW) is an endogenous
peptide
ligand for GPR8 (MIM 600731), a
G protein -coupled receptor.[supplied by OMIM]
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000183971 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000071230 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M (Sep 2002).
"Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7" . J Biol Chem . 277 (37): 34010–6.
doi :
10.1074/jbc.M205883200 .
PMID
12118011 .
^ Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M (Jan 2003).
"Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8" . J Biol Chem . 278 (2): 776–83.
doi :
10.1074/jbc.M206396200 .
PMID
12401809 .
^
a
b
"Entrez Gene: NPW neuropeptide W" .
Further reading
Singh G, Davenport AP (2006).
"Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system" . Br. J. Pharmacol . 148 (8): 1033–41.
doi :
10.1038/sj.bjp.0706825 .
PMC
1752024 .
PMID
16847439 .
Bonaldo MF, Lennon G, Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Shimomura Y, Harada M, Goto M, et al. (2002).
"Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8" . J. Biol. Chem . 277 (39): 35826–32.
doi :
10.1074/jbc.M205337200 .
PMID
12130646 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Tanaka H, Yoshida T, Miyamoto N, et al. (2003).
"Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8" . Proc. Natl. Acad. Sci. U.S.A . 100 (10): 6251–6.
Bibcode :
2003PNAS..100.6251T .
doi :
10.1073/pnas.0837789100 .
PMC
156358 .
PMID
12719537 .
Mondal MS, Yamaguchi H, Date Y, et al. (2003).
"A role for neuropeptide W in the regulation of feeding behavior" . Endocrinology . 144 (11): 4729–33.
doi :
10.1210/en.2003-0536 .
PMID
12959997 .
Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005).
"G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades" . J. Clin. Endocrinol. Metab . 90 (6): 3466–71.
doi :
10.1210/jc.2004-2132 .
PMID
15797961 .
Andreis PG, Rucinski M, Neri G, et al. (2006). "Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects". Int. J. Mol. Med . 16 (6): 1021–8.
doi :
10.3892/ijmm.16.6.1021 .
PMID
16273281 .
Mondal MS, Yamaguchi H, Date Y, et al. (2006).
"Neuropeptide W is present in antral G cells of rat, mouse, and human stomach" . J. Endocrinol . 188 (1): 49–57.
doi :
10.1677/joe.1.06195 .
PMID
16394174 .