Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a
protein receptor that in humans is encoded by the NOD1gene.[5][6] It recognizes bacterial molecules and stimulates an immune reaction .[7]
NOD1 protein contains a
caspase recruitment domain (CARD). NOD1 is a member of
NOD-like receptor protein family and is a close relative of
NOD2. NOD1 is an intracellular
pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates
innate and
acquired immunity by recognizing molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety, including bacterial
peptidoglycan. Nod1 interacts with
RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor
NF-κB.
Yoo NJ, Park WS, Kim SY, Reed JC, Son SG, Lee JY, Lee SH (December 2002). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochemical and Biophysical Research Communications. 299 (4): 652–8.
doi:
10.1016/S0006-291X(02)02714-6.
PMID12459189.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18.
doi:
10.1038/sj.onc.1206406.
PMID12761501.
S2CID38880905.
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a
protein receptor that in humans is encoded by the NOD1gene.[5][6] It recognizes bacterial molecules and stimulates an immune reaction .[7]
NOD1 protein contains a
caspase recruitment domain (CARD). NOD1 is a member of
NOD-like receptor protein family and is a close relative of
NOD2. NOD1 is an intracellular
pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates
innate and
acquired immunity by recognizing molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety, including bacterial
peptidoglycan. Nod1 interacts with
RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor
NF-κB.
Yoo NJ, Park WS, Kim SY, Reed JC, Son SG, Lee JY, Lee SH (December 2002). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochemical and Biophysical Research Communications. 299 (4): 652–8.
doi:
10.1016/S0006-291X(02)02714-6.
PMID12459189.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18.
doi:
10.1038/sj.onc.1206406.
PMID12761501.
S2CID38880905.