Names | |
---|---|
IUPAC name
N-(aminomethylidene)-L-glutamic acid
| |
Other names
FIGLU
| |
Identifiers | |
3D model (
JSmol)
|
|
ChemSpider | |
ECHA InfoCard | 100.011.308 |
MeSH | Formiminoglutamic+acid |
PubChem
CID
|
|
UNII | |
| |
Properties | |
C6H10N2O4 | |
Molar mass | 174.156 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Formiminoglutamic acid (FIGLU; conjugate base, formiminoglutamate) is an intermediate in the catabolism of L-histidine to L-glutamic acid. It thus is also a biomarker for intracellular levels of folate. The FIGLU test is used to identify vitamin B₁₂ deficiency, folate deficiency, and liver failure or liver disease. [1] [2] It is elevated with folate trapping, where it is accompanied by decreased methylmalonic acid, increased folate and a decrease in homocysteine. [3]
Names | |
---|---|
IUPAC name
N-(aminomethylidene)-L-glutamic acid
| |
Other names
FIGLU
| |
Identifiers | |
3D model (
JSmol)
|
|
ChemSpider | |
ECHA InfoCard | 100.011.308 |
MeSH | Formiminoglutamic+acid |
PubChem
CID
|
|
UNII | |
| |
Properties | |
C6H10N2O4 | |
Molar mass | 174.156 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Formiminoglutamic acid (FIGLU; conjugate base, formiminoglutamate) is an intermediate in the catabolism of L-histidine to L-glutamic acid. It thus is also a biomarker for intracellular levels of folate. The FIGLU test is used to identify vitamin B₁₂ deficiency, folate deficiency, and liver failure or liver disease. [1] [2] It is elevated with folate trapping, where it is accompanied by decreased methylmalonic acid, increased folate and a decrease in homocysteine. [3]