The following is a list of people from Guinea-Bissau.

• Amarildo Almeida (1976–), Olympic sprinter
• Fernando Arlete (sprinter) (1979–), Olympic sprinter
• Fernando Arlete (distance runner) (1968–), Olympic distance runner
• Fatumata Djau Baldé, politician
• Rafael Paula Barbosa (1926–2007), politician. Founded Democratic Social Front. Born in Safim.
• Suzi Barbosa, politician
• Francisco Benante (1954?–), lawyer and politician
• José Câmnate na Bissign (1953–), Roman Catholic bishop. Born in Mansôa.
• Alfredo Lopes Cabral (1946–), diplomat
• Amílcar Cabral (1924–1973), political organizer and diplomat. Born in Bafatá.
• Luís Cabral (1931–2009), first President. Born in Bissau.
• Maria da Conceição Nobre Cabral, politician
• Vasco Cabral (1926–2005), writer and politician. Born in Farim.
• Anhel Cape (1978–), Olympic sprinter
• Carlos Correia (1933–2021), former Prime Minister. Born in Bissau
• Manuel Saturnino da Costa (1942–), former Prime Minister
• Baciro Dabó (1958–2009), politician
• Yaya Diallo, former Foreign Minister
• Baciro Djá (1973–), former Prime Minister
• Umaro Djau (1967–), international journalist and politician. Born in Gabu Region
• Kimi Djabate (1975–), Afro-beat musician. Born in Tabato.
• Fausto Duarte (1903–1953), novelist. Born in Cape Verde.
• Umaro Sissoco Embaló (1972–), Prime Minister. Born in Bissau
• Francisco Fadul (1953–), former Prime Minister
• António Baticã Ferreira (1939–), poet. Born in Canchungo.
• Antonieta Rosa Gomes (1959–), politician. Founder of Guinean Civic Forum–Social Democracy party (FCG/SD).
• Aristides Gomes (1954–), former Prime Minister. Born in Canchungo.
• Fernando Gomes, politician
• Flora Gomes (1949–), film director. Born in Cadique.
• Carlos Gomes Júnior (1949–), former Prime Minister. Born in Bolama.
• Rogério Araújo Adolfo Herbert, diplomat
• Kumba Ialá (1953–2014), former president. Born in Bula.
• Faustino Imbali (1956–), former Prime Minister. Born in Ilondé.
• Jessica Inchude (1996–), Olympic shot-putter
• Zamora Induta (1966–), former Army Chief of Staff. Born in Bissau.
• Martinho Ndafa Kabi (1957–), former Prime Minister. Born in Nhacra.
• Mamadu Ture Kuruma, Army general
• Taciana Lima (1983–), Olympic judoka
• Carlo Lopes, economist
• Ansumane Mané (c.1940–2000), former Army Chief-of-Staff
• Victor Saúde Maria (1939–1999), former Prime Minister
• Eneida Marta (c.1973–), singer
• Bruno Medina (1987–), basketball player
• Francisco Mendes (1939–1978), former Prime Minister. Born in Enxude.
• Jacira Mendonca (1986–), Olympic wrestler
• António Isaac Monteiro, former Foreign Minister
• Edivaldo Monteiro (1976–), Olympic hurdler
• Maria do Céu Monteiro, President of Supreme Court
• Adiato Djaló Nandigna (1948–), politician
• Manuel Serifo Nhamadjo (1958–), politician
• Alamara Nhassé (1957–), former Prime Minister
• Caetano N'Tchama (1955–), former Prime Minister
• Carmen Pereira (1937–2016), activist and politician
• Domingos Simões Pereira (1963–), former Prime Minister
• Francisca Pereira (1942–), politician. Born in Bolama
• Raimundo Pereira (1956–), lawyer and politician, former interim President
• Benjamin Pinto Bull (1916–2005), politician and activist. Born in Bolama.
• Mamadu Saliu Djaló Pires, politician
• Mário Pires (1949–), former Prime Minister
• Fretïmio Assocão di Planka (1911–1971), politician
• Rajeshwar Prasad (1968–), entrepreneur and Cabinet Minister
• Helder Proença (?–2009), politician
• Adelino Mano Quetá, politician
• Danilson Ricciuli (1982–), Olympic sprinter
• Henrique Rosa (1946–2013), former interim President, 2003–5. Born in Bafatá
• Soares Sambú, politician
• Artur Sanhá (1965–), former Prime Minister
• Malam Bacai Sanhá (1947–2012), former president. Born in Darsalame.
• Mohamed Lamine Sanha (?–2007), Naval Chief of Staff
• José Carlos Schwarz (1945–1977), poet and musician. Born in Bissau.
• Veríssimo Correia Seabra (1947–2004), Army General. Born in Bissau.
• Odete Semedo (1959–), writer and educator
• Abdulai Silá (1958–), engineer and writer. Born in Catió.
• Emílio da Silva (1988–), footballer. Born in Bissau.
• Bubo Na Tchuto (1949–), former Navy Chief of Staff. Born in Incalá.
• Constantino Teixeira, former Prime Minister
• Filomena Mascarenhas Tipote (1969–), former Foreign Minister
• Domingas Togna (1981–), Olympic runner
• José Mário Vaz (1957–), President. Born in Calequisse.
• Zinha Vaz (1952–), activist and politician. Born in Bissau.
• João Bernardo Vieira (1939–2009), former President. Born in Bissau.
• Batista Tagme Na Waie (1949–2009), former Army Chief of Staff. Born in Catio.