KIAA1967, also known as Deleted in Breast Cancer 1, is a
protein which in humans is encoded by the KIAA1967gene.[5][6][7]
Function
Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase,
SIRT1, which deacetylates
histones and
p53.[8][9] DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.[10]
^Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27.
doi:
10.1093/dnares/8.6.319.
PMID11853319.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27.
doi:
10.1093/dnares/8.6.319.
PMID11853319.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105.
doi:
10.1038/ncb1086.
PMID14743216.
S2CID11683986.
Sundararajan R, Chen G, Mukherjee C, White E (2005). "Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling". Oncogene. 24 (31): 4908–20.
doi:
10.1038/sj.onc.1208681.
PMID15824730.
S2CID28591041.
KIAA1967, also known as Deleted in Breast Cancer 1, is a
protein which in humans is encoded by the KIAA1967gene.[5][6][7]
Function
Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase,
SIRT1, which deacetylates
histones and
p53.[8][9] DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.[10]
^Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27.
doi:
10.1093/dnares/8.6.319.
PMID11853319.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27.
doi:
10.1093/dnares/8.6.319.
PMID11853319.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105.
doi:
10.1038/ncb1086.
PMID14743216.
S2CID11683986.
Sundararajan R, Chen G, Mukherjee C, White E (2005). "Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling". Oncogene. 24 (31): 4908–20.
doi:
10.1038/sj.onc.1208681.
PMID15824730.
S2CID28591041.