Uncharacterized protein KIAA1377 is a
protein that in humans is encoded by the KIAA1377gene.[5][6]
Also known as Cep126, the protein has been shown to localize to the
centrosome. Furthermore, it is found at
pericentriolar satellites and the base of the
primary cilium. Depleting Cep126 leads to dispersion of pericentriolar satellites, in turn disrupting
microtubule organization at the
mitotic spindle.[7]
^Lim YM, Koh I, Park YM, Kim JJ, Kim DS, Kim HJ, Baik KH, Choi HY, Yang GS, Also-Rallo E, Tizzano EF, Gamez J, Park K, Yoo HW, Lee JK, Kim KK (Jan 18, 2012). "Exome sequencing identifies KIAA1377 and C5orf42 as susceptibility genes for monomelic amyotrophy". Neuromuscular Disorders. 22 (5): 394–400.
doi:
10.1016/j.nmd.2011.11.006.
PMID22264561.
S2CID41086322.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204.
PMID12107411.
Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608.
doi:
10.1093/hmg/ddg162.
PMID12812986.
Uncharacterized protein KIAA1377 is a
protein that in humans is encoded by the KIAA1377gene.[5][6]
Also known as Cep126, the protein has been shown to localize to the
centrosome. Furthermore, it is found at
pericentriolar satellites and the base of the
primary cilium. Depleting Cep126 leads to dispersion of pericentriolar satellites, in turn disrupting
microtubule organization at the
mitotic spindle.[7]
^Lim YM, Koh I, Park YM, Kim JJ, Kim DS, Kim HJ, Baik KH, Choi HY, Yang GS, Also-Rallo E, Tizzano EF, Gamez J, Park K, Yoo HW, Lee JK, Kim KK (Jan 18, 2012). "Exome sequencing identifies KIAA1377 and C5orf42 as susceptibility genes for monomelic amyotrophy". Neuromuscular Disorders. 22 (5): 394–400.
doi:
10.1016/j.nmd.2011.11.006.
PMID22264561.
S2CID41086322.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204.
PMID12107411.
Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608.
doi:
10.1093/hmg/ddg162.
PMID12812986.