KIAA0895 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | KIAA0895, 9530077C05Rik, 1110003N12Rik, Kiaa0895, mKIAA0895 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1915533; HomoloGene: 19280; GeneCards: KIAA0895; OMA: KIAA0895 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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KIAA0895 is a protein that in Homo sapiens is encoded by the KIAA0895 gene. The gene encodes a protein commonly known as the KIAA0895 protein. Its aliases include hypothetical protein LOC23366, OTTHUMP00000206979, OTTHUMP00000206980, 9530077C05Rik, and 1110003N12Rik. [5] It is located at 7p14.2. [6]
Research into the KIAA proteins has shown that they are similar to known genes with functions related to cell signaling/communication, cell structure/motility and nucleic acid management. [7]
The KIAA0895 gene is located at 7p14.2. [6] The genomic DNA is 65,976 base pairs long, [8] while the longest mRNA that it produces is 4463 bases long.
It can be transcribed into 15 transcript variants, which in turn can produce 13 different isoforms of the protein. [9]
KIAA0895 is surrounded by the following genes on chromosome 7: [8]
The gene encoded for the KIAA0895 protein is 65,975 nucleotides long, from nucleotides 36324150 to 36390125, with seven exons.
There are ten different isoforms for KIAA0895. [6]
The longest protein isoform that is produced by the KIAA0895 gene is termed LOC23366 isoform 1 and is 520 amino acids long. [10] The predicted molecular weight is 61kDa. [11] Additionally, the theoretical isoelectric point is 10. [11]
KIAA0895 is a lysine and arginine semi-enriched protein. [12] KIAA0895 is semi-enriched in positively charged lysine and arginine groups, and positively and negatively charged lysine, arginine, glutamic acid and aspartic acid groups. [12] However, KIAA0895 is semi-depleted in non-polar alanine, glycine and proline groups. [12]
The charge distribution analysis shows that there are no negative or mixed charge clusters. [12] However, there is one positive charge cluster from amino acids 12 to 36. [12]
Domain of unknown function 1704 | |||||||||
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Identifiers | |||||||||
Symbol | DUF1704 | ||||||||
Pfam | PF08014 | ||||||||
InterPro | IPR012548 | ||||||||
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LOC23366 contains a protein domain of unknown function called DUF1704. [13] It also contains a region of low complexity from position 120 to position 150 in the protein, [14] and an arginine-rich area from position 12 to position 51. [15]
Using ElDorado by Genomatrix, a promoter region sequence was found. [16] The most likely promoter for KIAA0895 starts at 36389926 and goes to 36391149, with a length of 1224. [16]
KIAA0895 is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout its structure. [17] Phosphorylation at these sites is a form of gene regulation. Phosphorylation results in a conformational change in the structure of many enzymes and receptors. This causes them to become activated or deactivated.
Using a database called Mfold, a stem-loop formation for the 5' UTR region shows that there is a lack of conservation, meaning there is some precedence that these stems and loops are not used for translation regulation. [18] The ΔG value was -12.90 kcal/mol with three loops. [18] Using the same database, a stem-loop formation for the 3' UTR region shows that there is conservation, meaning there is some precedence that they are used for translation regulation. [18] The ΔG value was -636.80 kcal/mol. [18]
KIAA0895 has a tertiary structure with alpha helices and beta sheets. [19]
There are three proteins likely to be interacting proteins with KIAA0895. These proteins are ELAVL1, [20] vata, [21] and glym. [21] These interactions have experimental evidence from the sources provided.
KIAA0895 is most commonly found in the testis, however it also has a strong expression in the kidneys, adrenal glands, and brain. [6]
Using an EST profile from NCBI, KIAA0895 has strong expression in cervical tumors and bladder carcinoma. [22]
Using three different databases, three different interacting proteins were found. These include ELAVL1, VATA, and GLYM. [21] There was experimental evidence for all three of these interacting proteins.
KIAA0895 has over 228 orthologs. [6] Orthologs have been found in mammals and eukaryotes. [23] There are homologs in 9 species. [6] The full list of organisms in which homologs have been found is given below.
KIAA0895 has 7 paralogs in Homo sapiens: [23]
KIAA0895 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | KIAA0895, 9530077C05Rik, 1110003N12Rik, Kiaa0895, mKIAA0895 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1915533; HomoloGene: 19280; GeneCards: KIAA0895; OMA: KIAA0895 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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KIAA0895 is a protein that in Homo sapiens is encoded by the KIAA0895 gene. The gene encodes a protein commonly known as the KIAA0895 protein. Its aliases include hypothetical protein LOC23366, OTTHUMP00000206979, OTTHUMP00000206980, 9530077C05Rik, and 1110003N12Rik. [5] It is located at 7p14.2. [6]
Research into the KIAA proteins has shown that they are similar to known genes with functions related to cell signaling/communication, cell structure/motility and nucleic acid management. [7]
The KIAA0895 gene is located at 7p14.2. [6] The genomic DNA is 65,976 base pairs long, [8] while the longest mRNA that it produces is 4463 bases long.
It can be transcribed into 15 transcript variants, which in turn can produce 13 different isoforms of the protein. [9]
KIAA0895 is surrounded by the following genes on chromosome 7: [8]
The gene encoded for the KIAA0895 protein is 65,975 nucleotides long, from nucleotides 36324150 to 36390125, with seven exons.
There are ten different isoforms for KIAA0895. [6]
The longest protein isoform that is produced by the KIAA0895 gene is termed LOC23366 isoform 1 and is 520 amino acids long. [10] The predicted molecular weight is 61kDa. [11] Additionally, the theoretical isoelectric point is 10. [11]
KIAA0895 is a lysine and arginine semi-enriched protein. [12] KIAA0895 is semi-enriched in positively charged lysine and arginine groups, and positively and negatively charged lysine, arginine, glutamic acid and aspartic acid groups. [12] However, KIAA0895 is semi-depleted in non-polar alanine, glycine and proline groups. [12]
The charge distribution analysis shows that there are no negative or mixed charge clusters. [12] However, there is one positive charge cluster from amino acids 12 to 36. [12]
Domain of unknown function 1704 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | DUF1704 | ||||||||
Pfam | PF08014 | ||||||||
InterPro | IPR012548 | ||||||||
|
LOC23366 contains a protein domain of unknown function called DUF1704. [13] It also contains a region of low complexity from position 120 to position 150 in the protein, [14] and an arginine-rich area from position 12 to position 51. [15]
Using ElDorado by Genomatrix, a promoter region sequence was found. [16] The most likely promoter for KIAA0895 starts at 36389926 and goes to 36391149, with a length of 1224. [16]
KIAA0895 is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout its structure. [17] Phosphorylation at these sites is a form of gene regulation. Phosphorylation results in a conformational change in the structure of many enzymes and receptors. This causes them to become activated or deactivated.
Using a database called Mfold, a stem-loop formation for the 5' UTR region shows that there is a lack of conservation, meaning there is some precedence that these stems and loops are not used for translation regulation. [18] The ΔG value was -12.90 kcal/mol with three loops. [18] Using the same database, a stem-loop formation for the 3' UTR region shows that there is conservation, meaning there is some precedence that they are used for translation regulation. [18] The ΔG value was -636.80 kcal/mol. [18]
KIAA0895 has a tertiary structure with alpha helices and beta sheets. [19]
There are three proteins likely to be interacting proteins with KIAA0895. These proteins are ELAVL1, [20] vata, [21] and glym. [21] These interactions have experimental evidence from the sources provided.
KIAA0895 is most commonly found in the testis, however it also has a strong expression in the kidneys, adrenal glands, and brain. [6]
Using an EST profile from NCBI, KIAA0895 has strong expression in cervical tumors and bladder carcinoma. [22]
Using three different databases, three different interacting proteins were found. These include ELAVL1, VATA, and GLYM. [21] There was experimental evidence for all three of these interacting proteins.
KIAA0895 has over 228 orthologs. [6] Orthologs have been found in mammals and eukaryotes. [23] There are homologs in 9 species. [6] The full list of organisms in which homologs have been found is given below.
KIAA0895 has 7 paralogs in Homo sapiens: [23]