| Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.83 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) ( EC 2.5.1.83, HexPS, hexaprenyl pyrophosphate synthetase, hexaprenyl diphosphate synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units). [1] [2] [3] This enzyme catalyses the following chemical reaction
- (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate 3 diphosphate + all-trans-hexaprenyl diphosphate
The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate.
References
- ^ Fujii H, Koyama T, Ogura K (December 1982). "Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components". The Journal of Biological Chemistry. 257 (24): 14610–2. doi: 10.1016/S0021-9258(18)33320-9. PMID 7174655.
- ^ Shimizu N, Koyama T, Ogura K (March 1998). "Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase". Journal of Bacteriology. 180 (6): 1578–81. doi: 10.1128/JB.180.6.1578-1581.1998. PMC 107062. PMID 9515931.
- ^ Nagaki M, Kimura K, Kimura H, Maki Y, Goto E, Nishino T, Koyama T (August 2001). "Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases". Bioorganic & Medicinal Chemistry Letters. 11 (16): 2157–9. doi: 10.1016/S0960-894X(01)00391-2. PMID 11514159.
External links
- Hexaprenyl-diphosphate+synthase+((2E,6E)-farnesyl-diphosphate+specific) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
| Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.83 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) ( EC 2.5.1.83, HexPS, hexaprenyl pyrophosphate synthetase, hexaprenyl diphosphate synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units). [1] [2] [3] This enzyme catalyses the following chemical reaction
- (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate 3 diphosphate + all-trans-hexaprenyl diphosphate
The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate.
References
- ^ Fujii H, Koyama T, Ogura K (December 1982). "Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components". The Journal of Biological Chemistry. 257 (24): 14610–2. doi: 10.1016/S0021-9258(18)33320-9. PMID 7174655.
- ^ Shimizu N, Koyama T, Ogura K (March 1998). "Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase". Journal of Bacteriology. 180 (6): 1578–81. doi: 10.1128/JB.180.6.1578-1581.1998. PMC 107062. PMID 9515931.
- ^ Nagaki M, Kimura K, Kimura H, Maki Y, Goto E, Nishino T, Koyama T (August 2001). "Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases". Bioorganic & Medicinal Chemistry Letters. 11 (16): 2157–9. doi: 10.1016/S0960-894X(01)00391-2. PMID 11514159.
External links
- Hexaprenyl-diphosphate+synthase+((2E,6E)-farnesyl-diphosphate+specific) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)