major histocompatibility complex, class II, DR53
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Haplotypes | DRA*01:DRB4*0101 DRA*01:DRB4*0102 DRA*01:DRB4*0103 DRA*01:DRB4*0104 | |
Structure (See HLA-DR) | ||
Identifiers | alpha *0101
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Symbol(s) | HLA-DRA[ permanent dead link] | |
EBI-HLA | DRA*0101 | |
Identifiers | beta 4 *0101 *0102 *0103 *0104
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Symbol(s) | HLA-DRB4[ permanent dead link] | |
EBI-HLA | DRB4*0101 | |
EBI-HLA | DRB4*0102 | |
EBI-HLA | DRB4*0103 | |
EBI-HLA | DRB4*0104 | |
Shared data | ||
Locus | chr.6 6p21.31 |
HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. [1] and the DRB4 locus presence is linked to HLA-DR7 seropositivity. The DRB4*locus was apparently duplicated from an ancestor of the DRB1-DRB4 common locus around 5 million years ago. [2]
DRB4 locus is only apparent in a small subset of DQ haplotypes, and most individuals lack DRB4. In addition the level of normal expression is 8 fold lower than the DRB1 in cells which can express both. [3] and lowered because of both transcriptional and post-transcriptional regulation. [4]
DRB4* | DR53 | ? | Sample |
allele | % | % | size (N) |
0101 | 95 | 38 | |
0103 | 89 | 49 |
DR53 reactive alleles: DRB4*0101, *0103
Unknown reactivity: *0102, *0104 to *0107
Null alleles: *0101102N, *01030102N, *0201N, *0301N
DRB4*01 is positively associated with Erythema multiforme, [6] Crohn's disease, [7] myasthenia gravis, [8] rheumatoid arthritis [9] Hashimoto's thyroiditis, [10] vitiligo, [11] primary biliary cirrhosis, [12] clozapine-induced agranulocytosis, [13] Vogt–Koyanagi–Harada disease, [14]
HLA-DR53 serotypes (HLA-DRB4) is linked to the following HLADR serotypes (HLA-DRB1) allele groups:
HLA-DR4 - DRB1*04
HLA-DR7 - DRB1*07
HLA-DR9 - DRB1*09
major histocompatibility complex, class II, DR53
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Haplotypes | DRA*01:DRB4*0101 DRA*01:DRB4*0102 DRA*01:DRB4*0103 DRA*01:DRB4*0104 | |
Structure (See HLA-DR) | ||
Identifiers | alpha *0101
| |
Symbol(s) | HLA-DRA[ permanent dead link] | |
EBI-HLA | DRA*0101 | |
Identifiers | beta 4 *0101 *0102 *0103 *0104
| |
Symbol(s) | HLA-DRB4[ permanent dead link] | |
EBI-HLA | DRB4*0101 | |
EBI-HLA | DRB4*0102 | |
EBI-HLA | DRB4*0103 | |
EBI-HLA | DRB4*0104 | |
Shared data | ||
Locus | chr.6 6p21.31 |
HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. [1] and the DRB4 locus presence is linked to HLA-DR7 seropositivity. The DRB4*locus was apparently duplicated from an ancestor of the DRB1-DRB4 common locus around 5 million years ago. [2]
DRB4 locus is only apparent in a small subset of DQ haplotypes, and most individuals lack DRB4. In addition the level of normal expression is 8 fold lower than the DRB1 in cells which can express both. [3] and lowered because of both transcriptional and post-transcriptional regulation. [4]
DRB4* | DR53 | ? | Sample |
allele | % | % | size (N) |
0101 | 95 | 38 | |
0103 | 89 | 49 |
DR53 reactive alleles: DRB4*0101, *0103
Unknown reactivity: *0102, *0104 to *0107
Null alleles: *0101102N, *01030102N, *0201N, *0301N
DRB4*01 is positively associated with Erythema multiforme, [6] Crohn's disease, [7] myasthenia gravis, [8] rheumatoid arthritis [9] Hashimoto's thyroiditis, [10] vitiligo, [11] primary biliary cirrhosis, [12] clozapine-induced agranulocytosis, [13] Vogt–Koyanagi–Harada disease, [14]
HLA-DR53 serotypes (HLA-DRB4) is linked to the following HLADR serotypes (HLA-DRB1) allele groups:
HLA-DR4 - DRB1*04
HLA-DR7 - DRB1*07
HLA-DR9 - DRB1*09