major histocompatibility complex, class II, DR53
| ||
Haplotypes groups | DRA*01:DRB3*01 DRA*01:DRB3*02 DRA*01:DRB3*03 | |
Structure (See HLA-DR) | ||
Identifiers | alpha *01:01
| |
Symbol(s) | HLA-DRA[ permanent dead link] | |
EBI-HLA | DRA*01:01 | |
Identifiers | beta 3 *01 *02 *03
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Symbol(s) | HLA-DRB3[ permanent dead link] | |
EBI-HLA | DRB3*01 | |
EBI-HLA | DRB3*02 | |
EBI-HLA | DRB3*03 Archived 2011-05-15 at the Wayback Machine | |
Shared data | ||
Locus | chr.6 6p21.31 |
HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.
DRB3, DRB4, and DRB5 are minor DR beta-encoding loci, and they have been recognized as having distinct evolution, [1] having diverged from DRB1 around 4 million years ago. [2]
The DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.
DRB3* | DR52 | ? | Sample |
allele | % | % | size (N) |
01:01 | 95 | 62 | |
01:02 | 99 | 1 | |
02:01 | 99 | 2 | |
02:02 | 95 | 100 | |
02:03 | 95 | 1 | |
03:01 | 95 | 36 |
DR52 serotype is positively associated with systemic sclerosis, [4] inflammatory myopathies, [5] inclusion body myositis, [6]
DRB3*01 is positively associated with sarcoidosis, [7] Grave's Disease, [8] [9] pulmonary sarcoidosis, [10]
DRB3*01:01:DRB1*03:01 is linked to Lofgren's syndrome [11]
DRB3*02:02 is also linked to Grave's disease, [9] serum IgG antibodies to Chlamydia pneumoniae with essential hypertension, [12] acute necrotizing encephalopathy [13]
DRB3*03:01 is weakly associated with anticardiolipin antibodies in SLE [14]
DRB3*03:01:DRB1*13:02 may be associated with Crohn's disease [15]
HLA-DRB3 is linked to these HLA-DR serotypes and DRB1 allele groups:
HLA-DR3 - DRB1*03
HLA-DR5 -
HLA-DR6 -
HLA-DR52 - Sjögren syndrome
major histocompatibility complex, class II, DR53
| ||
Haplotypes groups | DRA*01:DRB3*01 DRA*01:DRB3*02 DRA*01:DRB3*03 | |
Structure (See HLA-DR) | ||
Identifiers | alpha *01:01
| |
Symbol(s) | HLA-DRA[ permanent dead link] | |
EBI-HLA | DRA*01:01 | |
Identifiers | beta 3 *01 *02 *03
| |
Symbol(s) | HLA-DRB3[ permanent dead link] | |
EBI-HLA | DRB3*01 | |
EBI-HLA | DRB3*02 | |
EBI-HLA | DRB3*03 Archived 2011-05-15 at the Wayback Machine | |
Shared data | ||
Locus | chr.6 6p21.31 |
HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.
DRB3, DRB4, and DRB5 are minor DR beta-encoding loci, and they have been recognized as having distinct evolution, [1] having diverged from DRB1 around 4 million years ago. [2]
The DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.
DRB3* | DR52 | ? | Sample |
allele | % | % | size (N) |
01:01 | 95 | 62 | |
01:02 | 99 | 1 | |
02:01 | 99 | 2 | |
02:02 | 95 | 100 | |
02:03 | 95 | 1 | |
03:01 | 95 | 36 |
DR52 serotype is positively associated with systemic sclerosis, [4] inflammatory myopathies, [5] inclusion body myositis, [6]
DRB3*01 is positively associated with sarcoidosis, [7] Grave's Disease, [8] [9] pulmonary sarcoidosis, [10]
DRB3*01:01:DRB1*03:01 is linked to Lofgren's syndrome [11]
DRB3*02:02 is also linked to Grave's disease, [9] serum IgG antibodies to Chlamydia pneumoniae with essential hypertension, [12] acute necrotizing encephalopathy [13]
DRB3*03:01 is weakly associated with anticardiolipin antibodies in SLE [14]
DRB3*03:01:DRB1*13:02 may be associated with Crohn's disease [15]
HLA-DRB3 is linked to these HLA-DR serotypes and DRB1 allele groups:
HLA-DR3 - DRB1*03
HLA-DR5 -
HLA-DR6 -
HLA-DR52 - Sjögren syndrome