Identifiers | |
---|---|
3D model (
JSmol)
|
|
ChemSpider | |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C39H54N10O13S | |
Molar mass | 902.97 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
γ-Amanitin (gamma-Amanitin) is a cyclic peptide of eight amino acids. It is an amatoxin, a group of toxins isolated from and found in several members of the mushroom genus Amanita, one being the death cap ( Amanita phalloides) as well as the destroying angel, a complex of similar species, principally A. virosa and A. bisporigera. The compound is highly toxic, inhibits RNA polymerase II, disrupts synthesis of mRNA, and can be fatal. [1]
Amatoxins selectively inhibit Eukaryotic RNA polymerase II by tightly to the enzyme and severely inhibits translocation along the DNA template; thus the synthesis of mRNA and proteins stops. [2] Amatoxin consumption is characterized by a long asymptomatic period of a few hours (up to a day or more) followed by quick physiological decline due to acute hepatic and tubular necrosis. [3] γ-Amanitin has been found to have similar levels of toxicity to other amatoxins such as α-Amanitin.
Identifiers | |
---|---|
3D model (
JSmol)
|
|
ChemSpider | |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C39H54N10O13S | |
Molar mass | 902.97 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
γ-Amanitin (gamma-Amanitin) is a cyclic peptide of eight amino acids. It is an amatoxin, a group of toxins isolated from and found in several members of the mushroom genus Amanita, one being the death cap ( Amanita phalloides) as well as the destroying angel, a complex of similar species, principally A. virosa and A. bisporigera. The compound is highly toxic, inhibits RNA polymerase II, disrupts synthesis of mRNA, and can be fatal. [1]
Amatoxins selectively inhibit Eukaryotic RNA polymerase II by tightly to the enzyme and severely inhibits translocation along the DNA template; thus the synthesis of mRNA and proteins stops. [2] Amatoxin consumption is characterized by a long asymptomatic period of a few hours (up to a day or more) followed by quick physiological decline due to acute hepatic and tubular necrosis. [3] γ-Amanitin has been found to have similar levels of toxicity to other amatoxins such as α-Amanitin.