Guanylyl cyclase-activating protein 2 is proposed to play a role in
dark adaptation.[8] Under
scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate
guanylyl cyclase.[8] This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.
Laura RP, Hurley JB (August 1998). "The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2". Biochemistry. 37 (32): 11264–71.
doi:
10.1021/bi9809674.
PMID9698373.
Sokal I, Haeseleer F, Arendt A, Adman ET, Hargrave PA, Palczewski K (February 1999). "Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1". Biochemistry. 38 (5): 1387–93.
doi:
10.1021/bi982512k.
PMID9931003.
Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, et al. (June 2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Molecular Vision. 8: 196–204.
PMID12107411.
Sato M, Nakazawa M, Usui T, Tanimoto N, Abe H, Ohguro H (March 2005). "Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. 243 (3): 235–42.
doi:
10.1007/s00417-004-1015-7.
PMID15452722.
S2CID23347858.
Guanylyl cyclase-activating protein 2 is proposed to play a role in
dark adaptation.[8] Under
scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate
guanylyl cyclase.[8] This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.
Laura RP, Hurley JB (August 1998). "The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2". Biochemistry. 37 (32): 11264–71.
doi:
10.1021/bi9809674.
PMID9698373.
Sokal I, Haeseleer F, Arendt A, Adman ET, Hargrave PA, Palczewski K (February 1999). "Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1". Biochemistry. 38 (5): 1387–93.
doi:
10.1021/bi982512k.
PMID9931003.
Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, et al. (June 2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Molecular Vision. 8: 196–204.
PMID12107411.
Sato M, Nakazawa M, Usui T, Tanimoto N, Abe H, Ohguro H (March 2005). "Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. 243 (3): 235–42.
doi:
10.1007/s00417-004-1015-7.
PMID15452722.
S2CID23347858.