formimidoyltransferase cyclodeaminase
Formiminotransferase cyclodeaminase homooctamer, Rattus norvegicus
Identifiers
Symbol	FTCD
Alt. names	formiminotransferase cyclodeaminase
NCBI gene	10841
HGNC	3974
OMIM	606806
RefSeq	NM_006657
UniProt	O95954
Other data
Locus	Chr. 21 q22.3
Search for Structures Swiss-model Domains InterPro

Formimidoyltransferase cyclodeaminase or formiminotransferase cyclodeaminase (gene symbol FTCD in humans) is a bifunctional enzyme that catalyzes the following reactions: ^[1]

• conversion of formiminoglutamate and tetrahydrofolate into formiminotetrahydrofolate and glutamate ( glutamate formimidoyltransferase activity, EC 2.1.2.5)
• subsequent deamination of formiminotetrahydrofolate to 5,10-methenyltetrahydrofolate and ammonia ( formimidoyltetrahydrofolate cyclodeaminase activity, EC 4.3.1.4)

Its name comes from the two activities it catalyzes.

Mutations of the FTCD gene cause glutamate formiminotransferase deficiency. ^[1]

• Glutamate-1-semialdehyde