Fumarylacetoacetate hydrolase domain-containing protein 1, also known as FLJ36880 protein, is an
enzyme that in humans is encoded by the FAHD1gene on
chromosome 16.[4]
Structure
The FAHD1 gene encodes for a 24-kDa protein that is localized to the
mitochondrion and belongs to the
fumarylacetoacetate hydrolase family of proteins.[5] The structure of FAHD1 has been resolved using
X-ray crystallography at 2.2-Å resolution. The overall structure is similar to the C-terminal domain of the bifunctional enzyme HpcE from Escherichia coli C, fumarylacetoacetate hydrolase from Mus musculus and to YcgM (Apc5008) from E. coli 1262.[5] A number of conserved amino acids including Asp-102 and Arg-106 of FAHD1 appear to be important for its catalytic activity.[6]
Fumarylacetoacetate hydrolase domain-containing protein 1, also known as FLJ36880 protein, is an
enzyme that in humans is encoded by the FAHD1gene on
chromosome 16.[4]
Structure
The FAHD1 gene encodes for a 24-kDa protein that is localized to the
mitochondrion and belongs to the
fumarylacetoacetate hydrolase family of proteins.[5] The structure of FAHD1 has been resolved using
X-ray crystallography at 2.2-Å resolution. The overall structure is similar to the C-terminal domain of the bifunctional enzyme HpcE from Escherichia coli C, fumarylacetoacetate hydrolase from Mus musculus and to YcgM (Apc5008) from E. coli 1262.[5] A number of conserved amino acids including Asp-102 and Arg-106 of FAHD1 appear to be important for its catalytic activity.[6]