Exotoxin A | |||||||
---|---|---|---|---|---|---|---|
![]() Exotoxin A dimer, Pseudomonas aeruginosa | |||||||
Identifiers | |||||||
Organism | |||||||
Symbol | eta | ||||||
UniProt | P11439 | ||||||
Other data | |||||||
EC number | 2.4.2.36 | ||||||
|
The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. [1] Vibrio cholerae produces a similar protein called the Cholix toxin ( Q5EK40). [2]
It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of diphtheria toxin. [3]
It has been investigated as a treatment for hepatitis B [4] and cancer. [5]
Exotoxin A | |||||||
---|---|---|---|---|---|---|---|
![]() Exotoxin A dimer, Pseudomonas aeruginosa | |||||||
Identifiers | |||||||
Organism | |||||||
Symbol | eta | ||||||
UniProt | P11439 | ||||||
Other data | |||||||
EC number | 2.4.2.36 | ||||||
|
The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. [1] Vibrio cholerae produces a similar protein called the Cholix toxin ( Q5EK40). [2]
It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of diphtheria toxin. [3]
It has been investigated as a treatment for hepatitis B [4] and cancer. [5]