| Collagenous fibroma | |
|---|---|
| Specialty | Dermatology |
Collagenous fibroma, also known as desmoplastic fibroblastoma, is a slow-growing, deep-set, benign fibrous tumor, usually located in the deep subcutis, fascia, aponeurosis, or skeletal muscle of the extremities, limb girdles, or head and neck regions. [1]: 605 The World Health Organization in 2020 reclassified desmoplastic fibroblastoma/collagenous fibroma as a specific benign tumor type within the broad category of fibroblastic and myofibroblastic tumors. [2]
Signs and symptoms
Clinically, the lesion is observed as a hard, well-circumscribed, lobulated, round to oval, or fibrous mass that has a sparkling gray-to-white aspect and appears fibrous on the cut surface. [3] Patients with these tumors often appear with a history of a painless, slowly developing mass, often over a reasonably lengthy period of time. These tumors are mostly found in the subcutaneous and skeletal muscle tissues of the extremities. [4] These tumors usually have a diameter of 1 to 20 cm, with a median diameter of 3 cm. [5] [6]
Diagnosis
Collagenous fibroma is characterized histopathologically by long, sweeping fascicles of uniformly spindled cells that range in size from moderately to hypercellular. Long, thick-walled arteries exhibiting perivascular stromal edema are seen. [7] Gardner fibroma, nuchal-type fibroma, and desmoid tumor are examples of differential diagnoses. [8]
The fibroblastic cells have strong vimentin immunohistochemistry. [9] A small number of cells may exhibit positive immunoreactivity for alpha-smooth muscle actin and muscle-specific proteins. [6] The cells resemble fibroblasts or myofibroblasts in terms of ultrastructure. [5]
Treatment
Patients with collagenous fibroma who undergo marginal excision have good surgical results. [10] Video-assisted surgery has been suggested as a substitute for traditional open surgery in the removal of tumors on the chest wall because it minimizes tissue damage and allows for a smaller incision. [11] [12]
See also
References
- ^ James, William D.; Berger, Timothy G.; Elston, Dirk M.; Odom, Richard B. (2006). Andrews' diseases of the skin: clinical dermatology (10 ed.). Philadelphia: Saunders Elsevier. ISBN 978-0-7216-2921-6. OCLC 62736861.
- ^ Sbaraglia M, Bellan E, Dei Tos AP (April 2021). "The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives". Pathologica. 113 (2): 70–84. doi: 10.32074/1591-951X-213. PMC 8167394. PMID 33179614.
- ^ Hasegawa, T; Shimoda, T; Hirohashi, S; Hizawa, K; Sano, T (May 1998). "Collagenous fibroma (desmoplastic fibroblastoma): report of four cases and review of the literature". Archives of Pathology & Laboratory Medicine. 122 (5): 455–460. PMID 9593348.
- ^ Gong, Li-Hua; Liu, Wei-Feng; Ding, Yi; Geng, Yue-Hang; Sun, Xiao-Qi; Huang, Xiao-Yuan (2018-01-05). "Diagnosis and Differential Diagnosis of Desmoplastic Fibroblastoma by Clinical, Radiological, and Histopathological Analyses". Chinese Medical Journal. 131 (1). Ovid Technologies (Wolters Kluwer Health): 32–36. doi: 10.4103/0366-6999.221274. ISSN 0366-6999. PMC 5754955. PMID 29271377.
- ^ a b Harry, Evans (September 1995). "Desmoplastic fibroblastoma. A report of seven cases". The American Journal of Surgical Pathology. 19 (9): 1077–1081. doi: 10.1097/00000478-199509000-00012. PMID 7661281. Retrieved 20 April 2024.
- ^ a b Miettinen, Markku; Fetsch, John F (1998). "Collagenous fibroma (desmoplastic fibroblastoma): A clinicopathologic analysis of 63 cases of a distinctive soft tissue lesion with stellate-shaped fibroblasts". Human Pathology. 29 (7). Elsevier BV: 676–682. doi: 10.1016/s0046-8177(98)90275-1. ISSN 0046-8177. PMID 9670823.
- ^ Bakhshwin, Ahmed; Oaxaca, Gabriel; Armstrong, Susan; Ko, Jennifer; Billings, Steven (2023-09-04). "Superficial desmoplastic fibroblastoma (collagenous fibroma): Clinicopathologic study of 11 cases". Journal of Cutaneous Pathology. 51 (1). Wiley: 70–75. doi: 10.1111/cup.14529. ISSN 0303-6987. PMID 37666661.
- ^ Osipov, Vladimir; Carrera, Guillermo F. (2009). "Collagenous Fibroma (Desmoplastic Fibroblastoma) with Vertebral Body Erosion". Sarcoma. 2009. Hindawi Limited: 1–3. doi: 10.1155/2009/682687. ISSN 1357-714X. PMC 2688648. PMID 19503798.
- ^ Bhagalia, Sanjay; Jain, Manish; Pardhe, Nilesh; Sireesha, SundaragiriKrishna (2012). "Collagenous fibroma (desmoplastic fibroblastoma) of the oral cavity". Journal of Oral and Maxillofacial Pathology. 16 (2). Medknow: 277–279. doi: 10.4103/0973-029x.99089. ISSN 0973-029X. PMC 3424948. PMID 22923904.
- ^ Nakayama, Shizuhide; Nishio, Jun; Aoki, Mikiko; Nabeshima, Kazuki; Yamamoto, Takuaki (2021). "An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma)". In Vivo. 35 (1): 69–73. doi: 10.21873/invivo.12233. ISSN 0258-851X. PMC 7880796. PMID 33402451.
- ^ Giaccone, Agnese; Solli, Piergiorgio; Pardolesi, Alessandro; Brandolini, Jury; Bertolaccini, Luca (2017-05-26). "Video-assisted thoracoscopic surgery en bloc chest wall resection". Journal of Visualized Surgery. 3. AME Publishing Company: 73. doi: 10.21037/jovs.2017.04.04. ISSN 2221-2965. PMC 5637527. PMID 29078636.
- ^ Ota, Hideki; Ishida, Hirotaka; Matsumoto, Hidekazu; Ishiyama, Tomoharu (2021). "An extremely rare case of desmoplastic fibroblastoma exhibiting rapid growth in the chest wall: a case report". Surgical Case Reports. 7 (1): 86. doi: 10.1186/s40792-021-01171-1. ISSN 2198-7793. PMC 8026786. PMID 33829348.
Further reading
- Kresse, Maxine E.; Kransdorf, Mark J.; Fox, Michael G.; Flug, Jonathan A.; Long, Jeremiah R.; Murphey, Mark D. (2020). "Desmoplastic Fibroblastoma: An Uncommon Tumor With a Relatively Characteristic MRI Appearance". American Journal of Roentgenology. 215 (1): 178–183. doi: 10.2214/AJR.19.22163. ISSN 0361-803X. PMID 32406775.
- El-naggar, Hagar A.; El-Mahallawy, Yehia A.; Harby, Mohamed I.; Abou Madawi, Nourhan A. (2023-01-07). "Bilateral collagenous fibroma of the hard palate: a case report and review of the literature". Journal of Medical Case Reports. 17 (1): 5. doi: 10.1186/s13256-022-03691-2. ISSN 1752-1947. PMC 9824966. PMID 36609451.
External links
| Collagenous fibroma | |
|---|---|
| Specialty | Dermatology |
Collagenous fibroma, also known as desmoplastic fibroblastoma, is a slow-growing, deep-set, benign fibrous tumor, usually located in the deep subcutis, fascia, aponeurosis, or skeletal muscle of the extremities, limb girdles, or head and neck regions. [1]: 605 The World Health Organization in 2020 reclassified desmoplastic fibroblastoma/collagenous fibroma as a specific benign tumor type within the broad category of fibroblastic and myofibroblastic tumors. [2]
Signs and symptoms
Clinically, the lesion is observed as a hard, well-circumscribed, lobulated, round to oval, or fibrous mass that has a sparkling gray-to-white aspect and appears fibrous on the cut surface. [3] Patients with these tumors often appear with a history of a painless, slowly developing mass, often over a reasonably lengthy period of time. These tumors are mostly found in the subcutaneous and skeletal muscle tissues of the extremities. [4] These tumors usually have a diameter of 1 to 20 cm, with a median diameter of 3 cm. [5] [6]
Diagnosis
Collagenous fibroma is characterized histopathologically by long, sweeping fascicles of uniformly spindled cells that range in size from moderately to hypercellular. Long, thick-walled arteries exhibiting perivascular stromal edema are seen. [7] Gardner fibroma, nuchal-type fibroma, and desmoid tumor are examples of differential diagnoses. [8]
The fibroblastic cells have strong vimentin immunohistochemistry. [9] A small number of cells may exhibit positive immunoreactivity for alpha-smooth muscle actin and muscle-specific proteins. [6] The cells resemble fibroblasts or myofibroblasts in terms of ultrastructure. [5]
Treatment
Patients with collagenous fibroma who undergo marginal excision have good surgical results. [10] Video-assisted surgery has been suggested as a substitute for traditional open surgery in the removal of tumors on the chest wall because it minimizes tissue damage and allows for a smaller incision. [11] [12]
See also
References
- ^ James, William D.; Berger, Timothy G.; Elston, Dirk M.; Odom, Richard B. (2006). Andrews' diseases of the skin: clinical dermatology (10 ed.). Philadelphia: Saunders Elsevier. ISBN 978-0-7216-2921-6. OCLC 62736861.
- ^ Sbaraglia M, Bellan E, Dei Tos AP (April 2021). "The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives". Pathologica. 113 (2): 70–84. doi: 10.32074/1591-951X-213. PMC 8167394. PMID 33179614.
- ^ Hasegawa, T; Shimoda, T; Hirohashi, S; Hizawa, K; Sano, T (May 1998). "Collagenous fibroma (desmoplastic fibroblastoma): report of four cases and review of the literature". Archives of Pathology & Laboratory Medicine. 122 (5): 455–460. PMID 9593348.
- ^ Gong, Li-Hua; Liu, Wei-Feng; Ding, Yi; Geng, Yue-Hang; Sun, Xiao-Qi; Huang, Xiao-Yuan (2018-01-05). "Diagnosis and Differential Diagnosis of Desmoplastic Fibroblastoma by Clinical, Radiological, and Histopathological Analyses". Chinese Medical Journal. 131 (1). Ovid Technologies (Wolters Kluwer Health): 32–36. doi: 10.4103/0366-6999.221274. ISSN 0366-6999. PMC 5754955. PMID 29271377.
- ^ a b Harry, Evans (September 1995). "Desmoplastic fibroblastoma. A report of seven cases". The American Journal of Surgical Pathology. 19 (9): 1077–1081. doi: 10.1097/00000478-199509000-00012. PMID 7661281. Retrieved 20 April 2024.
- ^ a b Miettinen, Markku; Fetsch, John F (1998). "Collagenous fibroma (desmoplastic fibroblastoma): A clinicopathologic analysis of 63 cases of a distinctive soft tissue lesion with stellate-shaped fibroblasts". Human Pathology. 29 (7). Elsevier BV: 676–682. doi: 10.1016/s0046-8177(98)90275-1. ISSN 0046-8177. PMID 9670823.
- ^ Bakhshwin, Ahmed; Oaxaca, Gabriel; Armstrong, Susan; Ko, Jennifer; Billings, Steven (2023-09-04). "Superficial desmoplastic fibroblastoma (collagenous fibroma): Clinicopathologic study of 11 cases". Journal of Cutaneous Pathology. 51 (1). Wiley: 70–75. doi: 10.1111/cup.14529. ISSN 0303-6987. PMID 37666661.
- ^ Osipov, Vladimir; Carrera, Guillermo F. (2009). "Collagenous Fibroma (Desmoplastic Fibroblastoma) with Vertebral Body Erosion". Sarcoma. 2009. Hindawi Limited: 1–3. doi: 10.1155/2009/682687. ISSN 1357-714X. PMC 2688648. PMID 19503798.
- ^ Bhagalia, Sanjay; Jain, Manish; Pardhe, Nilesh; Sireesha, SundaragiriKrishna (2012). "Collagenous fibroma (desmoplastic fibroblastoma) of the oral cavity". Journal of Oral and Maxillofacial Pathology. 16 (2). Medknow: 277–279. doi: 10.4103/0973-029x.99089. ISSN 0973-029X. PMC 3424948. PMID 22923904.
- ^ Nakayama, Shizuhide; Nishio, Jun; Aoki, Mikiko; Nabeshima, Kazuki; Yamamoto, Takuaki (2021). "An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma)". In Vivo. 35 (1): 69–73. doi: 10.21873/invivo.12233. ISSN 0258-851X. PMC 7880796. PMID 33402451.
- ^ Giaccone, Agnese; Solli, Piergiorgio; Pardolesi, Alessandro; Brandolini, Jury; Bertolaccini, Luca (2017-05-26). "Video-assisted thoracoscopic surgery en bloc chest wall resection". Journal of Visualized Surgery. 3. AME Publishing Company: 73. doi: 10.21037/jovs.2017.04.04. ISSN 2221-2965. PMC 5637527. PMID 29078636.
- ^ Ota, Hideki; Ishida, Hirotaka; Matsumoto, Hidekazu; Ishiyama, Tomoharu (2021). "An extremely rare case of desmoplastic fibroblastoma exhibiting rapid growth in the chest wall: a case report". Surgical Case Reports. 7 (1): 86. doi: 10.1186/s40792-021-01171-1. ISSN 2198-7793. PMC 8026786. PMID 33829348.
Further reading
- Kresse, Maxine E.; Kransdorf, Mark J.; Fox, Michael G.; Flug, Jonathan A.; Long, Jeremiah R.; Murphey, Mark D. (2020). "Desmoplastic Fibroblastoma: An Uncommon Tumor With a Relatively Characteristic MRI Appearance". American Journal of Roentgenology. 215 (1): 178–183. doi: 10.2214/AJR.19.22163. ISSN 0361-803X. PMID 32406775.
- El-naggar, Hagar A.; El-Mahallawy, Yehia A.; Harby, Mohamed I.; Abou Madawi, Nourhan A. (2023-01-07). "Bilateral collagenous fibroma of the hard palate: a case report and review of the literature". Journal of Medical Case Reports. 17 (1): 5. doi: 10.1186/s13256-022-03691-2. ISSN 1752-1947. PMC 9824966. PMID 36609451.