Angiomyxoma | |
---|---|
![]() | |
Micrograph of an aggressive angiomyxoma. Core biopsy. H&E stain. | |
Specialty | Vascular system |
Angiomyxoma is a myxoid tumor involving the blood vessels.
It can affect the vulva [1] and other parts of the pelvis. The characteristic feature of this tumor is its frequent local recurrence and it is currently regarded as a non-metastasizing benign tumor. [2]
Immunohistochemical studies show strong staining for desmin, estrogen receptors, and progesterone receptors. Staining for actin, CD34 and smooth muscle actin are intermediate. Staining for S-100 protein is negative.
![]() | This section is empty. You can help by
adding to it. (October 2017) |
Although it is a benign tumour and does not invade neighbouring tissues, it has a tendency to recur after surgical excision so it is termed "aggressive". Recurrence can occur as early as six months from initial resection. Patients frequently present at tertiary medical centers with a history of labial mass (sometimes misdiagnosed as Gartner's cyst), with multiple surgical excisions from several surgeons. There is no standard medical therapy; agents reported to be effective in case reports include systemic hormonal therapy with SERMs such as tamoxifen or LHRH agonists ( leuprolide), and cytotoxic ("traditional") chemotherapy, as well as radiation therapy especially for recurrent disease.
Aggressive angiomyxoma was originally described in 1983, [8] but the term angiomyxoma dates back to at least 1952. [9]
Angiomyxoma | |
---|---|
![]() | |
Micrograph of an aggressive angiomyxoma. Core biopsy. H&E stain. | |
Specialty | Vascular system |
Angiomyxoma is a myxoid tumor involving the blood vessels.
It can affect the vulva [1] and other parts of the pelvis. The characteristic feature of this tumor is its frequent local recurrence and it is currently regarded as a non-metastasizing benign tumor. [2]
Immunohistochemical studies show strong staining for desmin, estrogen receptors, and progesterone receptors. Staining for actin, CD34 and smooth muscle actin are intermediate. Staining for S-100 protein is negative.
![]() | This section is empty. You can help by
adding to it. (October 2017) |
Although it is a benign tumour and does not invade neighbouring tissues, it has a tendency to recur after surgical excision so it is termed "aggressive". Recurrence can occur as early as six months from initial resection. Patients frequently present at tertiary medical centers with a history of labial mass (sometimes misdiagnosed as Gartner's cyst), with multiple surgical excisions from several surgeons. There is no standard medical therapy; agents reported to be effective in case reports include systemic hormonal therapy with SERMs such as tamoxifen or LHRH agonists ( leuprolide), and cytotoxic ("traditional") chemotherapy, as well as radiation therapy especially for recurrent disease.
Aggressive angiomyxoma was originally described in 1983, [8] but the term angiomyxoma dates back to at least 1952. [9]