Eliminative cleavage of dermatan sulfate containing (1→4)-β-D-hexosaminyl and (1→3)-β-D-glucurosonyl or (1→3)-α-L-iduronosyl linkages to disaccharides containing 4-deoxy-β-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (ΔUA-GalNAc-4S).
Glossary:
This enzyme belongs to the family of
lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The
systematic name of this enzyme class is chondroitin B lyase. Other names in common use include chondroitinase B, ChonB, and ChnB.
Pojasek K, Shriver Z, Kiley P, Venkataraman G, Sasisekharan R (2001). "Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum". Biochem. Biophys. Res. Commun. 286 (2): 343–51.
doi:
10.1006/bbrc.2001.5380.
PMID11500043.
Suzuki K, Terasaki Y, Uyeda M (2002). "Inhibition of hyaluronidases and chondroitinases by fatty acids". J. Enzyme. Inhib. Med. Chem. 17 (3): 183–6.
doi:
10.1080/14756360290032930.
PMID12443044.
Ototani N, Yosizawa Z (1979). "Purification of chondroitinase B and chondroitinase C using glycosaminoglycan-bound AH-Sepharose 4B". Carbohydr. Res. 70 (2): 295–306.
doi:
10.1016/S0008-6215(00)87109-8.
PMID427837.
Huang W, Matte A, Li Y, Kim YS, Linhardt RJ, Su H, Cygler M (1999). "Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution". J. Mol. Biol. 294 (5): 1257–69.
doi:
10.1006/jmbi.1999.3292.
PMID10600383.
Eliminative cleavage of dermatan sulfate containing (1→4)-β-D-hexosaminyl and (1→3)-β-D-glucurosonyl or (1→3)-α-L-iduronosyl linkages to disaccharides containing 4-deoxy-β-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (ΔUA-GalNAc-4S).
Glossary:
This enzyme belongs to the family of
lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The
systematic name of this enzyme class is chondroitin B lyase. Other names in common use include chondroitinase B, ChonB, and ChnB.
Pojasek K, Shriver Z, Kiley P, Venkataraman G, Sasisekharan R (2001). "Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum". Biochem. Biophys. Res. Commun. 286 (2): 343–51.
doi:
10.1006/bbrc.2001.5380.
PMID11500043.
Suzuki K, Terasaki Y, Uyeda M (2002). "Inhibition of hyaluronidases and chondroitinases by fatty acids". J. Enzyme. Inhib. Med. Chem. 17 (3): 183–6.
doi:
10.1080/14756360290032930.
PMID12443044.
Ototani N, Yosizawa Z (1979). "Purification of chondroitinase B and chondroitinase C using glycosaminoglycan-bound AH-Sepharose 4B". Carbohydr. Res. 70 (2): 295–306.
doi:
10.1016/S0008-6215(00)87109-8.
PMID427837.
Huang W, Matte A, Li Y, Kim YS, Linhardt RJ, Su H, Cygler M (1999). "Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution". J. Mol. Biol. 294 (5): 1257–69.
doi:
10.1006/jmbi.1999.3292.
PMID10600383.