From Wikipedia, the free encyclopedia
Protein-coding gene in humans
Cullin-7 is a RING-E3 ligase
protein that in humans is encoded by the CUL7
gene.
[5]
[6]
[7]
Clinical significance
It is associated with
3-M syndrome.
Interactions
CUL7 has been shown to
interact with
RBX1.
[5]
References
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000044090 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000038545 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^
a
b Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002).
"CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A. 99 (26): 16601–6.
doi:
10.1073/pnas.252646399.
PMC
139190.
PMID
12481031.
-
^ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003).
"Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A. 100 (17): 9855–60.
Bibcode:
2003PNAS..100.9855A.
doi:
10.1073/pnas.1733908100.
PMC
187864.
PMID
12904573.
-
^
"Entrez Gene: CUL7 cullin 7".
Further reading
- Kim SS, Shago M, Kaustov L, et al. (2007).
"CUL7 is a novel antiapoptotic oncogene". Cancer Res. 67 (20): 9616–22.
doi:
10.1158/0008-5472.CAN-07-0644.
PMID
17942889.
- Jung P, Verdoodt B, Bailey A, et al. (2007).
"Induction of cullin 7 by DNA damage attenuates p53 function". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11388–93.
Bibcode:
2007PNAS..10411388J.
doi:
10.1073/pnas.0609467104.
PMC
2040908.
PMID
17586686.
- Skaar JR, Florens L, Tsutsumi T, et al. (2007).
"PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14.
doi:
10.1158/0008-5472.CAN-06-3241.
PMID
17332328.
- Kaustov L, Lukin J, Lemak A, et al. (2007).
"The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53". J. Biol. Chem. 282 (15): 11300–7.
doi:
10.1074/jbc.M611297200.
PMID
17298945.
- Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7". Biochem. Biophys. Res. Commun. 348 (1): 132–8.
doi:
10.1016/j.bbrc.2006.07.013.
PMID
16875676.
- Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function". Oncogene. 25 (33): 4534–48.
doi:
10.1038/sj.onc.1209490.
PMID
16547496.
S2CID
36894787.
- Huber C, Dias-Santagata D, Glaser A, et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome". Nat. Genet. 37 (10): 1119–24.
doi:
10.1038/ng1628.
PMID
16142236.
S2CID
44003147.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003).
"The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11.
Bibcode:
2003Natur.425..805M.
doi:
10.1038/nature02055.
PMID
14574404.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Nakayama M, Kikuno R, Ohara O (2003).
"Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84.
doi:
10.1101/gr.406902.
PMC
187542.
PMID
12421765.
- Winston JT, Koepp DM, Zhu C, et al. (1999).
"A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2.
Bibcode:
1999CBio....9.1180W.
doi:
10.1016/S0960-9822(00)80021-4.
PMID
10531037.
S2CID
14341845.
- Nomura N, Nagase T, Miyajima N, et al. (1995).
"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9.
doi:
10.1093/dnares/1.5.223.
PMID
7584044.
External links