G1/S-specific cyclin-D2 is a
protein that in humans is encoded by the CCND2gene.[5]
Function
The
protein encoded by this gene belongs to the highly conserved
cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the
cell cycle. Cyclins function as regulators of cyclin-dependent kinases. Different cyclins exhibit distinct
expression and degradation patterns which contribute to the temporal coordination of each
mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK4 or
CDK6, whose activity is required for cell cycle
G1/
S transition. This protein has been shown to interact with and be involved in the
phosphorylation of
tumor suppressor protein
Rb.
Knockout studies of the
homologous gene in
mouse suggest the essential roles of this gene in
ovarian granulosa and
germ cell proliferation. High level expression of this gene was observed in
ovarian and
testiculartumors.[6]
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM (May 1993). "Functional interactions of the retinoblastoma protein with mammalian D-type cyclins". Cell. 73 (3): 487–97.
doi:
10.1016/0092-8674(93)90136-E.
PMID8343202.
S2CID41911038.
Palmero I, Holder A, Sinclair AJ, Dickson C, Peters G (Apr 1993). "Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines". Oncogene. 8 (4): 1049–54.
PMID8455931.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Sansal I, Dupont E, Toru D, Evrard C, Rouget P (Oct 2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9.
doi:
10.1038/sj.onc.1203843.
PMID11042687.
S2CID41370242.
G1/S-specific cyclin-D2 is a
protein that in humans is encoded by the CCND2gene.[5]
Function
The
protein encoded by this gene belongs to the highly conserved
cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the
cell cycle. Cyclins function as regulators of cyclin-dependent kinases. Different cyclins exhibit distinct
expression and degradation patterns which contribute to the temporal coordination of each
mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK4 or
CDK6, whose activity is required for cell cycle
G1/
S transition. This protein has been shown to interact with and be involved in the
phosphorylation of
tumor suppressor protein
Rb.
Knockout studies of the
homologous gene in
mouse suggest the essential roles of this gene in
ovarian granulosa and
germ cell proliferation. High level expression of this gene was observed in
ovarian and
testiculartumors.[6]
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM (May 1993). "Functional interactions of the retinoblastoma protein with mammalian D-type cyclins". Cell. 73 (3): 487–97.
doi:
10.1016/0092-8674(93)90136-E.
PMID8343202.
S2CID41911038.
Palmero I, Holder A, Sinclair AJ, Dickson C, Peters G (Apr 1993). "Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines". Oncogene. 8 (4): 1049–54.
PMID8455931.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Sansal I, Dupont E, Toru D, Evrard C, Rouget P (Oct 2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9.
doi:
10.1038/sj.onc.1203843.
PMID11042687.
S2CID41370242.