Chimerin 2 (beta-chimaerin) is a
protein that in humans is encoded by the CHN2gene.[4][5]
This gene is a member of the
chimerin family and encodes a protein with a
phorbol-ester/
diacylglycerol-type
zinc finger, a Rho-GAP domain and an SH2 domain. This protein has
GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the
cytosol to the
Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]
Yuan S, Miller DW, Barnett GH, et al. (1995). "Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma". Cancer Res. 55 (15): 3456–61.
PMID7614486.
Chimerin 2 (beta-chimaerin) is a
protein that in humans is encoded by the CHN2gene.[4][5]
This gene is a member of the
chimerin family and encodes a protein with a
phorbol-ester/
diacylglycerol-type
zinc finger, a Rho-GAP domain and an SH2 domain. This protein has
GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the
cytosol to the
Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]
Yuan S, Miller DW, Barnett GH, et al. (1995). "Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma". Cancer Res. 55 (15): 3456–61.
PMID7614486.