From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Centrosomal protein of 164 kDa , also known as CEP164 , is a
protein that in humans is encoded by the CEP164
gene .
[5]
[6]
Its function appears two be twofold: CEP164 is required for
primary cilium formation.
[7] Furthermore, it is an important component in the response to
DNA damage by
UV light .
[8]
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000110274 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000043987 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: centrosomal protein 164kDa" .
^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature . 426 (6966): 570–4.
Bibcode :
2003Natur.426..570A .
doi :
10.1038/nature02166 .
PMID
14654843 .
S2CID
4427303 .
^ Graser, S.; Stierhof, Y. -D.; Lavoie, S. B.; Gassner, O. S.; Lamla, S.; Le Clech, M.; Nigg, E. A. (2007).
"Cep164, a novel centriole appendage protein required for primary cilium formation" . The Journal of Cell Biology . 179 (2): 321–30.
doi :
10.1083/jcb.200707181 .
PMC
2064767 .
PMID
17954613 .
^ Sivasubramaniam, S.; Sun, X.; Pan, Y. -R.; Wang, S.;
Lee, E. Y. -H. P. (2008).
"Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1" . Genes & Development . 22 (5): 587–600.
doi :
10.1101/gad.1627708 .
PMC
2259029 .
PMID
18283122 .
^ Pan, YR; Lee, EY (2009).
"UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity" . Cell Cycle . 8 (4): 655–64.
doi :
10.4161/cc.8.4.7844 .
PMID
19197159 .
External links
Further reading
Graser S, Stierhof YD, Lavoie SB, et al. (2007).
"Cep164, a novel centriole appendage protein required for primary cilium formation" . J. Cell Biol . 179 (2): 321–30.
doi :
10.1083/jcb.200707181 .
PMC
2064767 .
PMID
17954613 .
Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995).
"Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function" . J. Cell Biol . 129 (6): 1617–28.
doi :
10.1083/jcb.129.6.1617 .
PMC
2291169 .
PMID
7790358 .
Casenghi M, Meraldi P, Weinhart U, et al. (2003).
"Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation" . Dev. Cell . 5 (1): 113–25.
doi :
10.1016/S1534-5807(03)00193-X .
PMID
12852856 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Mayor T, Stierhof YD, Tanaka K, et al. (2000).
"The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion" . J. Cell Biol . 151 (4): 837–46.
doi :
10.1083/jcb.151.4.837 .
PMC
2169446 .
PMID
11076968 .
Sivasubramaniam S, Sun X, Pan YR, et al. (2008).
"Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1" . Genes Dev . 22 (5): 587–600.
doi :
10.1101/gad.1627708 .
PMC
2259029 .
PMID
18283122 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Petretti C, Savoian M, Montembault E, et al. (2006).
"The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation" . EMBO Rep . 7 (4): 418–24.
doi :
10.1038/sj.embor.7400639 .
PMC
1456919 .
PMID
16462731 .
Zick A, Onn I, Bezalel R, et al. (2005).
"Assigning functions to genes: identification of S-phase expressed genes in Leishmania major based on post-transcriptional control elements" . Nucleic Acids Res . 33 (13): 4235–42.
doi :
10.1093/nar/gki742 .
PMC
1181863 .
PMID
16052032 .
Pan YR, Lee EY (2009).
"UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity" . Cell Cycle . 8 (4): 655–64.
doi :
10.4161/cc.8.4.7844 .
PMID
19197159 .
Takahashi M, Yamagiwa A, Nishimura T, et al. (2002).
"Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex" . Mol. Biol. Cell . 13 (9): 3235–45.
doi :
10.1091/mbc.E02-02-0112 .
PMC
124155 .
PMID
12221128 .