The
protein encoded by this gene is highly
homologous to
alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit
phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with
Alzheimer's disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with
Parkinson's disease; however, no direct relation to Parkinson's disease has been established. Two transcript variants encoding the same protein have been found for this gene.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Spillantini MG, Divane A, Goedert M (Nov 1995). "Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35". Genomics. 27 (2): 379–81.
doi:
10.1006/geno.1995.1063.
PMID7558013.
Rockenstein E, Hansen LA, Mallory M, et al. (2001). "Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease". Brain Res. 914 (1–2): 48–56.
doi:
10.1016/S0006-8993(01)02772-X.
PMID11578596.
S2CID35448948.
Fung KM, Rorke LB, Giasson B, et al. (2003). "Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas". Acta Neuropathol. 106 (2): 167–75.
doi:
10.1007/s00401-003-0718-x.
PMID12783249.
S2CID39712533.
The
protein encoded by this gene is highly
homologous to
alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit
phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with
Alzheimer's disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with
Parkinson's disease; however, no direct relation to Parkinson's disease has been established. Two transcript variants encoding the same protein have been found for this gene.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Spillantini MG, Divane A, Goedert M (Nov 1995). "Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35". Genomics. 27 (2): 379–81.
doi:
10.1006/geno.1995.1063.
PMID7558013.
Rockenstein E, Hansen LA, Mallory M, et al. (2001). "Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease". Brain Res. 914 (1–2): 48–56.
doi:
10.1016/S0006-8993(01)02772-X.
PMID11578596.
S2CID35448948.
Fung KM, Rorke LB, Giasson B, et al. (2003). "Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas". Acta Neuropathol. 106 (2): 167–75.
doi:
10.1007/s00401-003-0718-x.
PMID12783249.
S2CID39712533.