From Wikipedia, the free encyclopedia
BRCA1 C Terminus (BRCT) domain
Structure of an XRCC1 BRCT domain. [1]
Identifiers
SymbolBRCT
Pfam PF00533
InterPro IPR001357
SCOP2 1cdz / SCOPe / SUPFAM
CDD cd00027
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary
PDB 2azmB:1906-1957 2adoB:1906-1957 2etxA:1906-1957

1kzyC:1795-1835 1l0bA:1589-1669 1t2vC:1646-1723 1n5oX:1646-1723 1t2uA:1646-1723 1jnxX:1646-1723 1t15A:1646-1723 1t29A:1646-1723 1y98A:1646-1723 2couA:91-166 1l7bA:589-664 2cokA:385-463 1wf6A:354-431 1ik9C:681-717 1cdzA:538-616

1oqaA:1756-1842 2coeA:27-111

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.

The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage, [2] for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain. [3]

Examples

Human proteins containing this domain include:

References

  1. ^ Zhang X, Moréra S, Bates PA, et al. (November 1998). "Structure of an XRCC1 BRCT domain: a new protein-protein interaction module". EMBO J. 17 (21): 6404–11. doi: 10.1093/emboj/17.21.6404. PMC  1170965. PMID  9799248.
  2. ^ Bork P, Hofmann K, Koonin EV, Bucher P, Neuwald AF, Altschul SF (1997). "A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins". FASEB J. 11 (1): 68–76. doi: 10.1096/fasebj.11.1.9034168. PMID  9034168. S2CID  16457619.
  3. ^ Yu X, Chini CC, He M, Mer G, Chen J (2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–642. Bibcode: 2003Sci...302..639Y. doi: 10.1126/science.1088753. PMID  14576433. S2CID  29407635.

External links

This article incorporates text from the public domain Pfam and InterPro: IPR001357


From Wikipedia, the free encyclopedia
BRCA1 C Terminus (BRCT) domain
Structure of an XRCC1 BRCT domain. [1]
Identifiers
SymbolBRCT
Pfam PF00533
InterPro IPR001357
SCOP2 1cdz / SCOPe / SUPFAM
CDD cd00027
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary
PDB 2azmB:1906-1957 2adoB:1906-1957 2etxA:1906-1957

1kzyC:1795-1835 1l0bA:1589-1669 1t2vC:1646-1723 1n5oX:1646-1723 1t2uA:1646-1723 1jnxX:1646-1723 1t15A:1646-1723 1t29A:1646-1723 1y98A:1646-1723 2couA:91-166 1l7bA:589-664 2cokA:385-463 1wf6A:354-431 1ik9C:681-717 1cdzA:538-616

1oqaA:1756-1842 2coeA:27-111

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.

The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage, [2] for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain. [3]

Examples

Human proteins containing this domain include:

References

  1. ^ Zhang X, Moréra S, Bates PA, et al. (November 1998). "Structure of an XRCC1 BRCT domain: a new protein-protein interaction module". EMBO J. 17 (21): 6404–11. doi: 10.1093/emboj/17.21.6404. PMC  1170965. PMID  9799248.
  2. ^ Bork P, Hofmann K, Koonin EV, Bucher P, Neuwald AF, Altschul SF (1997). "A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins". FASEB J. 11 (1): 68–76. doi: 10.1096/fasebj.11.1.9034168. PMID  9034168. S2CID  16457619.
  3. ^ Yu X, Chini CC, He M, Mer G, Chen J (2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–642. Bibcode: 2003Sci...302..639Y. doi: 10.1126/science.1088753. PMID  14576433. S2CID  29407635.

External links

This article incorporates text from the public domain Pfam and InterPro: IPR001357



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