BRCA1 C Terminus (BRCT) domain | |||||||||||
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Identifiers | |||||||||||
Symbol | BRCT | ||||||||||
Pfam | PF00533 | ||||||||||
InterPro | IPR001357 | ||||||||||
SCOP2 | 1cdz / SCOPe / SUPFAM | ||||||||||
CDD | cd00027 | ||||||||||
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BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.
The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage, [2] for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain. [3]
Human proteins containing this domain include:
BRCA1 C Terminus (BRCT) domain | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||
Symbol | BRCT | ||||||||||
Pfam | PF00533 | ||||||||||
InterPro | IPR001357 | ||||||||||
SCOP2 | 1cdz / SCOPe / SUPFAM | ||||||||||
CDD | cd00027 | ||||||||||
|
BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.
The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage, [2] for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain. [3]
Human proteins containing this domain include: