From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Pescadillo homolog is a
protein that in humans is encoded by the PES1
gene .
[5]
[6]
[7]
[8]
This gene encodes a protein that is abnormally elevated in
malignant tumors of
astrocytic origin. It is a strongly conserved gene containing a
BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for
oncogenic transformation and tumor progression.
[8]
^
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b
c
GRCh38: Ensembl release 89: ENSG00000100029 –
Ensembl , May 2017
^
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b
c
GRCm38: Ensembl release 89: ENSMUSG00000020430 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
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^ Rohrmoser M, Holzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D (May 2007).
"Interdependence of Pes1, Bop1, and WDR12 Controls Nucleolar Localization and Assembly of the PeBoW Complex Required for Maturation of the 60S Ribosomal Subunit" . Mol Cell Biol . 27 (10): 3682–94.
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PMC
1899993 .
PMID
17353269 .
^
a
b
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PMC
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PMID
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PMID
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PMID
15467761 .
S2CID
7435460 .
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PMID
15635413 .
S2CID
4344740 .
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PMC
2171466 .
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16043514 .
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