ASPARTYL AMINOPEPTIDASE

Aspartyl aminopeptidase
Aspartyl aminopeptidase
	Aspartyl aminopeptidase dodekamer, Bos taurus
Identifiers
EC no.	3.4.11.21
CAS no.	9074-83-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Aspartyl aminopeptidase ( EC 3.4.11.21) is an enzyme.^[1]^[2] This enzyme catalyses the following chemical reaction

Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate

Aminoacyl-arylamides are poor substrates.

References

^ Kelly JA, Neidle EL, Neidle A (June 1983). "An aminopeptidase from mouse brain cytosol that cleaves N-terminal acidic amino acid residues". Journal of Neurochemistry. 40 (6): 1727–34. doi: 10.1111/j.1471-4159.1983.tb08148.x. PMID 6854330. S2CID 25470156.
^ Wilk S, Wilk E, Magnusson RP (June 1998). "Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase". The Journal of Biological Chemistry. 273 (26): 15961–70. doi: 10.1074/jbc.273.26.15961. PMID 9632644.

Aspartyl+aminopeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases ( list) EC2 Transferases ( list) EC3 Hydrolases ( list) EC4 Lyases ( list) EC5 Isomerases ( list) EC6 Ligases ( list) EC7 Translocases ( list)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases ( list) EC2 Transferases ( list) EC3 Hydrolases ( list) EC4 Lyases ( list) EC5 Isomerases ( list) EC6 Ligases ( list) EC7 Translocases ( list)