All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) | |||||||||
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Identifiers | |||||||||
EC no. | 2.5.1.85 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) ( EC 2.5.1.85, nonaprenyl diphosphate synthase, solanesyl diphosphate synthase, At-SPS2, At-SPS1, SPS1, SPS2) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units). [1] [2] [3] This enzyme catalyses the following chemical reaction
Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate.
In 2020, aclonifen was shown to inhibit the enzyme and is the first compound to have this mechanism of action as a herbicide. [4]
All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 2.5.1.85 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
|
All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) ( EC 2.5.1.85, nonaprenyl diphosphate synthase, solanesyl diphosphate synthase, At-SPS2, At-SPS1, SPS1, SPS2) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units). [1] [2] [3] This enzyme catalyses the following chemical reaction
Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate.
In 2020, aclonifen was shown to inhibit the enzyme and is the first compound to have this mechanism of action as a herbicide. [4]