From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
AKAP9 Identifiers
Aliases
AKAP9 , AKAP-9, AKAP350, AKAP450, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO, A-kinase anchoring protein 9External IDs
OMIM :
604001 ;
HomoloGene :
17517 ;
GeneCards :
AKAP9 ;
OMA :
AKAP9 - orthologs
Wikidata
A-kinase anchor protein 9 is a
protein that in humans is encoded by the AKAP9
gene .
[3]
[4]
[5] AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450
[6]
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of
protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in many isoforms that localize to the centrosome and the
Golgi apparatus , and interact with numerous signaling proteins from multiple
signal transduction pathways. These signaling proteins include type II protein kinase A,
serine/threonine kinase protein kinase N ,
protein phosphatase 1 ,
protein phosphatase 2a ,
protein kinase C-epsilon and
phosphodiesterase 4D3 .
[5]
AKAP9 has been shown to
interact with:
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000127914 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, Sheng M (Apr 1998).
"Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1" . J Neurosci . 18 (6): 2017–27.
doi :
10.1523/JNEUROSCI.18-06-02017.1998 .
PMC
6792910 .
PMID
9482789 .
^ Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD (Jul 1999). "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex". Science . 285 (5424): 93–6.
doi :
10.1126/science.285.5424.93 .
PMID
10390370 .
^
a
b
"Entrez Gene: AKAP9 A kinase (PRKA) anchor protein (yotiao) 9" .
^ Ong ST, Chalasani ML, Fazil MH, Prasannan P, Kizhakeyil A, Wright GD, Kelleher D, Verma NK (Mar 2018).
"Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells" . Front. Immunol . 9 (397): 397.
doi :
10.3389/fimmu.2018.00397 .
PMC
5837996 .
PMID
29545805 .
^
a
b Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (Sep 2002).
"Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex" . Mol. Biol. Cell . 13 (9): 3235–45.
doi :
10.1091/mbc.E02-02-0112 .
PMC
124155 .
PMID
12221128 .
^
a
b Larocca MC, Shanks RA, Tian L, Nelson DL, Stewart DM, Goldenring JR (Jun 2004).
"AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus" . Mol. Biol. Cell . 15 (6): 2771–81.
doi :
10.1091/mbc.E03-10-0757 .
PMC
420101 .
PMID
15047863 .
^ Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS (Jan 2002). "Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel". Science . 295 (5554): 496–9.
Bibcode :
2002Sci...295..496M .
doi :
10.1126/science.1066843 .
PMID
11799244 .
S2CID
6153394 .
^
a
b Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y (Jun 1999).
"Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus" . J. Biol. Chem . 274 (24): 17267–74.
doi :
10.1074/jbc.274.24.17267 .
PMID
10358086 .
^ Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003).
"Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring" . Proc. Natl. Acad. Sci. U.S.A . 100 (8): 4445–50.
Bibcode :
2003PNAS..100.4445A .
doi :
10.1073/pnas.0330734100 .
PMC
153575 .
PMID
12672969 .
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999).
"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 5 (5): 277–86.
doi :
10.1093/dnares/5.5.277 .
PMID
9872452 .
Schmidt PH, Dransfield DT, Claudio JO, Hawley RG, Trotter KW, Milgram SL, Goldenring JR (1999).
"AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes" . J. Biol. Chem . 274 (5): 3055–66.
doi :
10.1074/jbc.274.5.3055 .
PMID
9915845 .
Witczak O, Skålhegg BS, Keryer G, Bornens M, Taskén K, Jahnsen T, Orstavik S (1999).
"Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450" . EMBO J . 18 (7): 1858–68.
doi :
10.1093/emboj/18.7.1858 .
PMC
1171271 .
PMID
10202149 .
Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y (1999).
"Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus" . J. Biol. Chem . 274 (24): 17267–74.
doi :
10.1074/jbc.274.24.17267 .
PMID
10358086 .
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci . 3 (7): 661–9.
doi :
10.1038/76615 .
hdl :
1842/742 .
PMID
10862698 .
S2CID
14392630 .
Takahashi M, Mukai H, Oishi K, Isagawa T, Ono Y (2000).
"Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP" . J. Biol. Chem . 275 (44): 34592–6.
doi :
10.1074/jbc.M005285200 .
PMID
10945988 .
Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS (2002). "Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel". Science . 295 (5554): 496–9.
Bibcode :
2002Sci...295..496M .
doi :
10.1126/science.1066843 .
PMID
11799244 .
S2CID
6153394 .
Steadman BT, Schmidt PH, Shanks RA, Lapierre LA, Goldenring JR (2002).
"Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus" . J. Biol. Chem . 277 (33): 30165–76.
doi :
10.1074/jbc.M201914200 .
PMID
12015314 .
Bray JD, Chennathukuzhi VM, Hecht NB (2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics . 79 (6): 799–808.
doi :
10.1006/geno.2002.6779 .
PMID
12036294 .
Shanks RA, Larocca MC, Berryman M, Edwards JC, Urushidani T, Navarre J, Goldenring JR (2002).
"AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member" . J. Biol. Chem . 277 (43): 40973–80.
doi :
10.1074/jbc.M112277200 .
PMID
12163479 .
Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (2003).
"Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex" . Mol. Biol. Cell . 13 (9): 3235–45.
doi :
10.1091/mbc.E02-02-0112 .
PMC
124155 .
PMID
12221128 .
Sillibourne JE, Milne DM, Takahashi M, Ono Y, Meek DW (2002). "Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450". J. Mol. Biol . 322 (4): 785–97.
doi :
10.1016/S0022-2836(02)00857-4 .
PMID
12270714 .
Tu H, Tang TS, Wang Z, Bezprozvanny I (2004).
"Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A" . J. Biol. Chem . 279 (18): 19375–82.
doi :
10.1074/jbc.M313476200 .
PMID
14982933 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .