cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an
enzyme that in humans is encoded by the PDE4Dgene.
Function
The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM][5]
^Steele MR, McCahill A, Thompson DS, MacKenzie C, Isaacs NW, Houslay MD, Bolger GB (Jul 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cellular Signalling. 13 (7): 507–13.
doi:
10.1016/S0898-6568(01)00167-X.
PMID11516626.
^Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current Pharmaceutical Design. 15 (14): 1688–98.
doi:
10.2174/138161209788168092.
PMID19442182.
Milatovich A, Bolger G, Michaeli T, Francke U (Mar 1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somatic Cell and Molecular Genetics. 20 (2): 75–86.
doi:
10.1007/BF02290677.
PMID8009369.
S2CID19182571.
Baecker PA, Obernolte R, Bach C, Yee C, Shelton ER (Jan 1994). "Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)". Gene. 138 (1–2): 253–6.
doi:
10.1016/0378-1119(94)90818-4.
PMID8125310.
Miró X, Casacuberta JM, Gutiérrez-López MD, de Landázuri MO, Puigdomènech P (Aug 2000). "Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1)". Biochemical and Biophysical Research Communications. 274 (2): 415–21.
doi:
10.1006/bbrc.2000.3146.
PMID10913353.
Steele MR, McCahill A, Thompson DS, MacKenzie C, Isaacs NW, Houslay MD, Bolger GB (Jul 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cellular Signalling. 13 (7): 507–13.
doi:
10.1016/S0898-6568(01)00167-X.
PMID11516626.
Gretarsdottir S, Sveinbjörnsdottir S, Jonsson HH, Jakobsson F, Einarsdottir E, Agnarsson U, Shkolny D, Einarsson G, Gudjonsdottir HM, Valdimarsson EM, Einarsson OB, Thorgeirsson G, Hadzic R, Jonsdottir S, Reynisdottir ST, Bjarnadottir SM, Gudmundsdottir T, Gudlaugsdottir GJ, Gill R, Lindpaintner K, Sainz J, Hannesson HH, Sigurdsson GT, Frigge ML, Kong A, Gudnason V, Stefansson K, Gulcher JR (Mar 2002).
"Localization of a susceptibility gene for common forms of stroke to 5q12". American Journal of Human Genetics. 70 (3): 593–603.
doi:
10.1086/339252.
PMC384939.
PMID11833004.
Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A (Feb 2002). "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia". Clinical Cancer Research. 8 (2): 589–95.
PMID11839681.
cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an
enzyme that in humans is encoded by the PDE4Dgene.
Function
The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM][5]
^Steele MR, McCahill A, Thompson DS, MacKenzie C, Isaacs NW, Houslay MD, Bolger GB (Jul 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cellular Signalling. 13 (7): 507–13.
doi:
10.1016/S0898-6568(01)00167-X.
PMID11516626.
^Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current Pharmaceutical Design. 15 (14): 1688–98.
doi:
10.2174/138161209788168092.
PMID19442182.
Milatovich A, Bolger G, Michaeli T, Francke U (Mar 1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somatic Cell and Molecular Genetics. 20 (2): 75–86.
doi:
10.1007/BF02290677.
PMID8009369.
S2CID19182571.
Baecker PA, Obernolte R, Bach C, Yee C, Shelton ER (Jan 1994). "Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)". Gene. 138 (1–2): 253–6.
doi:
10.1016/0378-1119(94)90818-4.
PMID8125310.
Miró X, Casacuberta JM, Gutiérrez-López MD, de Landázuri MO, Puigdomènech P (Aug 2000). "Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1)". Biochemical and Biophysical Research Communications. 274 (2): 415–21.
doi:
10.1006/bbrc.2000.3146.
PMID10913353.
Steele MR, McCahill A, Thompson DS, MacKenzie C, Isaacs NW, Houslay MD, Bolger GB (Jul 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cellular Signalling. 13 (7): 507–13.
doi:
10.1016/S0898-6568(01)00167-X.
PMID11516626.
Gretarsdottir S, Sveinbjörnsdottir S, Jonsson HH, Jakobsson F, Einarsdottir E, Agnarsson U, Shkolny D, Einarsson G, Gudjonsdottir HM, Valdimarsson EM, Einarsson OB, Thorgeirsson G, Hadzic R, Jonsdottir S, Reynisdottir ST, Bjarnadottir SM, Gudmundsdottir T, Gudlaugsdottir GJ, Gill R, Lindpaintner K, Sainz J, Hannesson HH, Sigurdsson GT, Frigge ML, Kong A, Gudnason V, Stefansson K, Gulcher JR (Mar 2002).
"Localization of a susceptibility gene for common forms of stroke to 5q12". American Journal of Human Genetics. 70 (3): 593–603.
doi:
10.1086/339252.
PMC384939.
PMID11833004.
Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A (Feb 2002). "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia". Clinical Cancer Research. 8 (2): 589–95.
PMID11839681.