| 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.183 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase ( EC 2.1.1.183, 18S rRNA dimethylase Dim1p, Dim1p, ScDim1, m2(6)A dimethylase, KIDIM1) is an enzyme with systematic name S-adenosyl-L-methionine:18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction
- 4 S-adenosyl-L-methionine + adenine1779/ adenine1780 in 18S rRNA 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA
DIM1 is involved in pre-rRNA processing.
References
- ^ Lafontaine D, Vandenhaute J, Tollervey D (October 1995). "The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast". Genes & Development. 9 (20): 2470–81. doi: 10.1101/gad.9.20.2470. PMID 7590228.
- ^ Lafontaine DL, Preiss T, Tollervey D (April 1998). "Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?". Molecular and Cellular Biology. 18 (4): 2360–70. doi: 10.1128/mcb.18.4.2360. PMC 121492. PMID 9528805.
- ^ Pulicherla N, Pogorzala LA, Xu Z, O Farrell HC, Musayev FN, Scarsdale JN, Sia EA, Culver GM, Rife JP (September 2009). "Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases". Journal of Molecular Biology. 391 (5): 884–93. doi: 10.1016/j.jmb.2009.06.015. PMC 2753216. PMID 19520088.
- ^ Lafontaine D, Delcour J, Glasser AL, Desgrès J, Vandenhaute J (August 1994). "The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast". Journal of Molecular Biology. 241 (3): 492–7. doi: 10.1006/jmbi.1994.1525. PMID 8064863.
- ^ O'Farrell HC, Pulicherla N, Desai PM, Rife JP (May 2006). "Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution". RNA. 12 (5): 725–33. doi: 10.1261/rna.2310406. PMC 1440906. PMID 16540698.
External links
- 18S+rRNA+(adenine1779-N6/adenine1780-N6)-dimethyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
| 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.183 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase ( EC 2.1.1.183, 18S rRNA dimethylase Dim1p, Dim1p, ScDim1, m2(6)A dimethylase, KIDIM1) is an enzyme with systematic name S-adenosyl-L-methionine:18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction
- 4 S-adenosyl-L-methionine + adenine1779/ adenine1780 in 18S rRNA 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA
DIM1 is involved in pre-rRNA processing.
References
- ^ Lafontaine D, Vandenhaute J, Tollervey D (October 1995). "The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast". Genes & Development. 9 (20): 2470–81. doi: 10.1101/gad.9.20.2470. PMID 7590228.
- ^ Lafontaine DL, Preiss T, Tollervey D (April 1998). "Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?". Molecular and Cellular Biology. 18 (4): 2360–70. doi: 10.1128/mcb.18.4.2360. PMC 121492. PMID 9528805.
- ^ Pulicherla N, Pogorzala LA, Xu Z, O Farrell HC, Musayev FN, Scarsdale JN, Sia EA, Culver GM, Rife JP (September 2009). "Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases". Journal of Molecular Biology. 391 (5): 884–93. doi: 10.1016/j.jmb.2009.06.015. PMC 2753216. PMID 19520088.
- ^ Lafontaine D, Delcour J, Glasser AL, Desgrès J, Vandenhaute J (August 1994). "The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast". Journal of Molecular Biology. 241 (3): 492–7. doi: 10.1006/jmbi.1994.1525. PMID 8064863.
- ^ O'Farrell HC, Pulicherla N, Desai PM, Rife JP (May 2006). "Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution". RNA. 12 (5): 725–33. doi: 10.1261/rna.2310406. PMC 1440906. PMID 16540698.
External links
- 18S+rRNA+(adenine1779-N6/adenine1780-N6)-dimethyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)