14-3-3 protein epsilon is a
protein that in humans is encoded by the YWHAEgene.[5]
Function
This gene product belongs to the
14-3-3 family of proteins which mediate
signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases,
RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of
insulin sensitivity. It has also been implicated in the pathogenesis of
small cell lung cancer,[6] and microdeletions associated with
Miller–Dieker syndrome.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Luk SC, Garcia-Barcelo M, Tsui SK, Fung KP, Lee CY, Waye MM (December 1997). "Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization". Cytogenet Cell Genet. 78 (2): 105–6.
doi:
10.1159/000134638.
PMID9371399.
Jones DH, Ley S, Aitken A (1995). "Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins". FEBS Lett. 368 (1): 55–8.
doi:
10.1016/0014-5793(95)00598-4.
PMID7615088.
S2CID7233378.
Finlin BS, Andres DA (1999). "Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins". Arch. Biochem. Biophys. 368 (2): 401–12.
doi:
10.1006/abbi.1999.1316.
PMID10441394.
14-3-3 protein epsilon is a
protein that in humans is encoded by the YWHAEgene.[5]
Function
This gene product belongs to the
14-3-3 family of proteins which mediate
signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases,
RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of
insulin sensitivity. It has also been implicated in the pathogenesis of
small cell lung cancer,[6] and microdeletions associated with
Miller–Dieker syndrome.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Luk SC, Garcia-Barcelo M, Tsui SK, Fung KP, Lee CY, Waye MM (December 1997). "Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization". Cytogenet Cell Genet. 78 (2): 105–6.
doi:
10.1159/000134638.
PMID9371399.
Jones DH, Ley S, Aitken A (1995). "Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins". FEBS Lett. 368 (1): 55–8.
doi:
10.1016/0014-5793(95)00598-4.
PMID7615088.
S2CID7233378.
Finlin BS, Andres DA (1999). "Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins". Arch. Biochem. Biophys. 368 (2): 401–12.
doi:
10.1006/abbi.1999.1316.
PMID10441394.