From Wikipedia, the free encyclopedia
(Carboxyethyl)arginine β-lactam-synthase
beta-lactam synthetase. PDB 1mc1 [1]
Identifiers
EC no. 6.3.3.4
CAS no. 68247-54-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a (carboxyethyl)arginine β-lactam-synthase ( EC 6.3.3.4) is an enzyme that catalyzes the chemical reaction

ATP + L-N2-(2-carboxyethyl)arginine AMP + diphosphate + deoxyamidinoproclavaminate

Thus, the two substrates of this enzyme are ATP and L-N2-(2-carboxyethyl)arginine, whereas its 3 products are AMP, diphosphate, and deoxyamidinoproclavaminate.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme is also called L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme participates in clavulanic acid biosynthesis.

References

  1. ^ Miller, M. T.; Bachmann, B. O.; Townsend, C. A.; Rosenzweig, A. C. (2002). "The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots". Proceedings of the National Academy of Sciences. 99 (23): 14752–14757. Bibcode: 2002PNAS...9914752M. doi: 10.1073/pnas.232361199. PMC  137491. PMID  12409610.

Further reading


From Wikipedia, the free encyclopedia
(Carboxyethyl)arginine β-lactam-synthase
beta-lactam synthetase. PDB 1mc1 [1]
Identifiers
EC no. 6.3.3.4
CAS no. 68247-54-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a (carboxyethyl)arginine β-lactam-synthase ( EC 6.3.3.4) is an enzyme that catalyzes the chemical reaction

ATP + L-N2-(2-carboxyethyl)arginine AMP + diphosphate + deoxyamidinoproclavaminate

Thus, the two substrates of this enzyme are ATP and L-N2-(2-carboxyethyl)arginine, whereas its 3 products are AMP, diphosphate, and deoxyamidinoproclavaminate.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme is also called L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme participates in clavulanic acid biosynthesis.

References

  1. ^ Miller, M. T.; Bachmann, B. O.; Townsend, C. A.; Rosenzweig, A. C. (2002). "The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots". Proceedings of the National Academy of Sciences. 99 (23): 14752–14757. Bibcode: 2002PNAS...9914752M. doi: 10.1073/pnas.232361199. PMC  137491. PMID  12409610.

Further reading



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