This article may need to be rewritten to comply with Wikipedia's
quality standards. (March 2020) |
Names | |
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Preferred IUPAC name
(3R,4R)-3,4-Bis[(2H-1,3-benzodioxol-5-yl)methyl]oxolan-2-one | |
Other names
(3R,4R)-3,4-Bis(1,3-benzodioxol-5-ylmethyl)dihydro-2(3H)-furanone
| |
Identifiers | |
3D model (
JSmol)
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ChEMBL | |
ChemSpider | |
PubChem
CID
|
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CompTox Dashboard (
EPA)
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Properties | |
C20H18O6 | |
Molar mass | 354.358 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Hinokinin is a dibenzylbutyrolactone lignan, derived from various species of plants. It is a potential antichagonistic agent. [1] In vitro, it has been shown to have potential neuroprotective effects [2] as well as anti-inflammatory, anti-tumor, antiviral and antifungal properties. [3]
Hinokinin was isolated for the first time by Yoshiki and Ishiguro in 1933 from hinoki wood. [4]
Hinokinin is a colourless crystalline compound.[ citation needed]
It can be isolated from various species of Chamaecyparis, Zanthoxylum, Phyllanthus, Aristolochia, Piper, Virola, Linum and Bursera. It is also synthesised from pinoresinol. [1]
Hinokinin has shown to induce apoptosis and promote antitumor actions on various cancer cell lines in vitro. [5]
Hinokinin has been shown to inhibit the generation of superoxide molecules by neutrophils and also decreases elastase secretion from neutrophils. [6] It has also shown to reduce LPS induced nitric oxide production from macrophages.The anti-inflammatory property of hinokinin is mediated by the NF-kB signalling mechanism. [7]
Hinokinin has been shown to be an antitrypanosomal agent. Its use as a treatment for trypanosomiasis is still being researched. [8]
It has shown significant antiviral activity against human hepatitis B virus, HIV and SARS-CoV. [9]
This article may need to be rewritten to comply with Wikipedia's
quality standards. (March 2020) |
Names | |
---|---|
Preferred IUPAC name
(3R,4R)-3,4-Bis[(2H-1,3-benzodioxol-5-yl)methyl]oxolan-2-one | |
Other names
(3R,4R)-3,4-Bis(1,3-benzodioxol-5-ylmethyl)dihydro-2(3H)-furanone
| |
Identifiers | |
3D model (
JSmol)
|
|
ChEMBL | |
ChemSpider | |
PubChem
CID
|
|
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C20H18O6 | |
Molar mass | 354.358 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Hinokinin is a dibenzylbutyrolactone lignan, derived from various species of plants. It is a potential antichagonistic agent. [1] In vitro, it has been shown to have potential neuroprotective effects [2] as well as anti-inflammatory, anti-tumor, antiviral and antifungal properties. [3]
Hinokinin was isolated for the first time by Yoshiki and Ishiguro in 1933 from hinoki wood. [4]
Hinokinin is a colourless crystalline compound.[ citation needed]
It can be isolated from various species of Chamaecyparis, Zanthoxylum, Phyllanthus, Aristolochia, Piper, Virola, Linum and Bursera. It is also synthesised from pinoresinol. [1]
Hinokinin has shown to induce apoptosis and promote antitumor actions on various cancer cell lines in vitro. [5]
Hinokinin has been shown to inhibit the generation of superoxide molecules by neutrophils and also decreases elastase secretion from neutrophils. [6] It has also shown to reduce LPS induced nitric oxide production from macrophages.The anti-inflammatory property of hinokinin is mediated by the NF-kB signalling mechanism. [7]
Hinokinin has been shown to be an antitrypanosomal agent. Its use as a treatment for trypanosomiasis is still being researched. [8]
It has shown significant antiviral activity against human hepatitis B virus, HIV and SARS-CoV. [9]