From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Zinc finger FYVE domain-containing protein 1 is a
protein that in humans is encoded by the ZFYVE1
gene.
[5]
[6]
[7]
The
FYVE domain mediates the recruitment of proteins involved in
membrane trafficking and
cell signaling to
phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two
zinc-binding FYVE domains in tandem. This protein displays a predominantly
Golgi,
endoplasmic reticulum and
vesicular distribution.
Alternatively spliced
transcript variants have been found for this gene, and they encode two
isoforms with different sizes.
[7]
References
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000165861 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000042628 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^ Derubeis AR, Young MF, Jia L, Robey PG, Fisher LW (Nov 2000).
"Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library". Gene. 255 (2): 195–203.
doi:
10.1016/S0378-1119(00)00303-6.
PMID
11024279.
-
^ Cheung PC, Trinkle-Mulcahy L, Cohen P, Lucocq JM (Mar 2001).
"Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi". Biochem J. 355 (Pt 1): 113–21.
doi:
10.1042/0264-6021:3550113.
PMC
1221718.
PMID
11256955.
- ^
a
b
"Entrez Gene: ZFYVE1 zinc finger, FYVE domain containing 1".
Further reading
- Nagase T, Kikuno R, Nakayama M, et al. (2001).
"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81.
doi:
10.1093/dnares/7.4.271.
PMID
10997877.
- Ridley SH, Ktistakis N, Davidson K, et al. (2002).
"FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments" (PDF). J. Cell Sci. 114 (Pt 22): 3991–4000.
doi:
10.1242/jcs.114.22.3991.
PMID
11739631.
- Krugmann S, Anderson KE, Ridley SH, et al. (2002).
"Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell. 9 (1): 95–108.
doi:
10.1016/S1097-2765(02)00434-3.
PMID
11804589.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Heilig R, Eckenberg R, Petit JL, et al. (2003).
"The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7.
Bibcode:
2003Natur.421..601H.
doi:
10.1038/nature01348.
PMID
12508121.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5.
doi:
10.1038/ng1285.
PMID
14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Wan D, Gong Y, Qin W, et al. (2004).
"Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9.
Bibcode:
2004PNAS..10115724W.
doi:
10.1073/pnas.0404089101.
PMC
524842.
PMID
15498874.