From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Exportin-T is a
protein that in humans is encoded by the XPOT
gene .
[5]
[6]
[7]
This gene encodes a protein belonging to the
RAN-GTPase exportin family that mediates export of
tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once
exportin has bound both tRNA and GTP-bound RAN.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000184575 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000034667 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998).
"Identification of a tRNA-specific nuclear export receptor" . Mol Cell . 1 (3): 359–69.
doi :
10.1016/S1097-2765(00)80036-2 .
PMID
9660920 .
^ Arts GJ, Fornerod M, Mattaj IW (May 1998).
"Identification of a nuclear export receptor for tRNA" . Curr Biol . 8 (6): 305–14.
doi :
10.1016/S0960-9822(98)70130-7 .
PMID
9512417 .
S2CID
17803674 .
^
a
b
"Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)" .
Further reading
Arts GJ, Kuersten S, Romby P, et al. (1999).
"The role of exportin-t in selective nuclear export of mature tRNAs" . EMBO J . 17 (24): 7430–41.
doi :
10.1093/emboj/17.24.7430 .
PMC
1171087 .
PMID
9857198 .
Kruse C, Willkomm DK, Grünweller A, et al. (2000).
"Export and transport of tRNA are coupled to a multi-protein complex" . Biochem. J . 346 (1): 107–15.
doi :
10.1042/0264-6021:3460107 .
PMC
1220829 .
PMID
10657246 .
Kutay U, Hartmann E, Treichel N, et al. (2001).
"Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily" . J. Biol. Chem . 275 (51): 40163–8.
doi :
10.1074/jbc.M006242200 .
hdl :
11858/00-001M-0000-0015-3D4E-B .
PMID
11024021 .
Kuersten S, Arts GJ, Walther TC, et al. (2002).
"Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains" . Mol. Cell. Biol . 22 (16): 5708–20.
doi :
10.1128/MCB.22.16.5708-5720.2002 .
PMC
133969 .
PMID
12138183 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Suzuki T, Koyama Y, Hayakawa S, et al. (2006).
"1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells" . Biomed. Res . 27 (2): 89–92.
doi :
10.2220/biomedres.27.89 .
PMID
16707848 .
Li S, Sprinzl M (2007).
"Interaction of immobilized human exportin-t with calf liver tRNA" . RNA Biol . 3 (4): 145–9.
doi :
10.4161/rna.3.4.3679 .
PMID
17224653 .