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As a trans person in STEM / going to medical school, the ability of the business decisions of one or two companies to disrupt the hormone supply chain in the US concerns me, so I like to keep abreast of "the state of the art," just in case I have the ability to influence the situation in the distant future. Marker degradation is an old procedure, so I wonder if it's still performed with hexavalent chromium. Maybe I'm searching wrong, but I can't find any new methods that use a substitute for hexavalent chromium, which is environmentally toxic (and just uncool).
What happens if one uses ozonolysis instead of chromic acid to open the cyclic enol ether "furan" ring in the second step of the Marker degradation? The oxidative workup of ozonolysis typically results in carboxylic acids. Can one obtain esters with either the reductive or oxidative workup? The ester group is hydrolyzed in the third and final step of the Marker degradation anyway, with the 16-OH eliminated. Yanping Nora Soong ( talk) 17:38, 7 September 2022 (UTC)
Science desk | ||
---|---|---|
< September 6 | << Aug | September | Oct >> | September 8 > |
Welcome to the Wikipedia Science Reference Desk Archives |
---|
The page you are currently viewing is a transcluded archive page. While you can leave answers for any questions shown below, please ask new questions on one of the current reference desk pages. |
As a trans person in STEM / going to medical school, the ability of the business decisions of one or two companies to disrupt the hormone supply chain in the US concerns me, so I like to keep abreast of "the state of the art," just in case I have the ability to influence the situation in the distant future. Marker degradation is an old procedure, so I wonder if it's still performed with hexavalent chromium. Maybe I'm searching wrong, but I can't find any new methods that use a substitute for hexavalent chromium, which is environmentally toxic (and just uncool).
What happens if one uses ozonolysis instead of chromic acid to open the cyclic enol ether "furan" ring in the second step of the Marker degradation? The oxidative workup of ozonolysis typically results in carboxylic acids. Can one obtain esters with either the reductive or oxidative workup? The ester group is hydrolyzed in the third and final step of the Marker degradation anyway, with the 16-OH eliminated. Yanping Nora Soong ( talk) 17:38, 7 September 2022 (UTC)