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As EMTs, we are told to safeguard our albuterol sulfate (salbuterol) from high temperatures (like a poorly air-conditioned ambulance front cabin on a hot summer day), light and other stressors. I can see why, as my basic organic chem training tells me the ortho/para dialkylphenol ring in salbuterol is electron-rich and the hydroxymethylene group is a fairly decent general acid/base catalyst (sort of like the 2-OH group in RNA?). Thus the clarity, color and consistency of our nebulizable albuterol supplies must be constantly monitored as it can go bad prior to its relatively short expiration date if stored improperly.
The steroidal nature of over the counter nebulized budesonide seems less susceptible to oxidation but I notice there is a conjugated dienone functionality with a possibly activated / vulnerable neighboring C-H bond. How sensitive is budenoside to heat, light and oxidation relative to salbuterol? Yanping Nora Soong ( talk) 03:25, 16 February 2020 (UTC)
Science desk | ||
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< February 15 | << Jan | February | Mar >> | Current desk > |
Welcome to the Wikipedia Science Reference Desk Archives |
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The page you are currently viewing is a transcluded archive page. While you can leave answers for any questions shown below, please ask new questions on one of the current reference desk pages. |
As EMTs, we are told to safeguard our albuterol sulfate (salbuterol) from high temperatures (like a poorly air-conditioned ambulance front cabin on a hot summer day), light and other stressors. I can see why, as my basic organic chem training tells me the ortho/para dialkylphenol ring in salbuterol is electron-rich and the hydroxymethylene group is a fairly decent general acid/base catalyst (sort of like the 2-OH group in RNA?). Thus the clarity, color and consistency of our nebulizable albuterol supplies must be constantly monitored as it can go bad prior to its relatively short expiration date if stored improperly.
The steroidal nature of over the counter nebulized budesonide seems less susceptible to oxidation but I notice there is a conjugated dienone functionality with a possibly activated / vulnerable neighboring C-H bond. How sensitive is budenoside to heat, light and oxidation relative to salbuterol? Yanping Nora Soong ( talk) 03:25, 16 February 2020 (UTC)