WWE protein domain | |||||||||
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![]() Solution structure of WWE domain in BAB28015 | |||||||||
Identifiers | |||||||||
Symbol | WWE | ||||||||
Pfam | PF02825 | ||||||||
InterPro | IPR004170 | ||||||||
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The WWE domains occur in two functional classes of proteins, namely those associated with ubiquitination and those associated with poly-ADP ribosylation ( PARP). Hence, WWE domains hold an important function in signal transduction, protein degradation, DNA repair and apoptosis. [1]
The WWE domain is named after three of its conserved residues, W and E residues ( tryptophans and glutamate respectively), and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems (Poly ADP ribose polymerase). This domain is found as a tandem repeat at the N-terminal of Deltex, a cytosolic effector of Notch signalling thought to bind the N-terminal of the Notch receptor. [2] It is also found as an interaction module in protein ubiquination and ADP ribosylation proteins. [1]
Within each WWE module, the residues form two similar structures vital to its stability. The two WWE modules interact and form a large cleft suitable for binding of extended polypeptides. The two WWE modules adopt compact structures mostly composed of beta strands, with a single three turn alpha helix in both modules and an additional short helical segment in the second WWE module. The two WWE modules hold a two-fold rotation axis. [2]
WWE protein domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
![]() Solution structure of WWE domain in BAB28015 | |||||||||
Identifiers | |||||||||
Symbol | WWE | ||||||||
Pfam | PF02825 | ||||||||
InterPro | IPR004170 | ||||||||
|
The WWE domains occur in two functional classes of proteins, namely those associated with ubiquitination and those associated with poly-ADP ribosylation ( PARP). Hence, WWE domains hold an important function in signal transduction, protein degradation, DNA repair and apoptosis. [1]
The WWE domain is named after three of its conserved residues, W and E residues ( tryptophans and glutamate respectively), and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems (Poly ADP ribose polymerase). This domain is found as a tandem repeat at the N-terminal of Deltex, a cytosolic effector of Notch signalling thought to bind the N-terminal of the Notch receptor. [2] It is also found as an interaction module in protein ubiquination and ADP ribosylation proteins. [1]
Within each WWE module, the residues form two similar structures vital to its stability. The two WWE modules interact and form a large cleft suitable for binding of extended polypeptides. The two WWE modules adopt compact structures mostly composed of beta strands, with a single three turn alpha helix in both modules and an additional short helical segment in the second WWE module. The two WWE modules hold a two-fold rotation axis. [2]