WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a
protein that in humans is encoded by the WIPI1gene.[5][6][7]
Structure and function
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a
beta-propeller platform for simultaneous and reversible
protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with
phospholipids.[5][7]
^
abProikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25.
doi:
10.1038/sj.onc.1208331.
PMID15602573.
S2CID22642893.
WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a
protein that in humans is encoded by the WIPI1gene.[5][6][7]
Structure and function
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a
beta-propeller platform for simultaneous and reversible
protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with
phospholipids.[5][7]
^
abProikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25.
doi:
10.1038/sj.onc.1208331.
PMID15602573.
S2CID22642893.