Wnt inhibitory factor 1 is a
protein that in humans is encoded by the WIF1gene.[5] WIF1 is a
lipid-binding protein that binds to
Wnt proteins and prevents them from triggering signalling.[6][7][8]
Function
WNT proteins are extracellular signaling molecules involved in the control of
embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in
mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.[5]
Reguart N, He B, Xu Z, et al. (2004). "Cloning and characterization of the promoter of human Wnt inhibitory factor-1". Biochem. Biophys. Res. Commun. 323 (1): 229–34.
doi:
10.1016/j.bbrc.2004.08.075.
PMID15351726.
Esufali S, Bapat B (2004). "Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation". Oncogene. 23 (50): 8260–71.
doi:
10.1038/sj.onc.1208007.
PMID15377999.
S2CID30877665.
Ohigashi T, Mizuno R, Nakashima J, et al. (2005). "Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells". Prostate. 62 (1): 61–8.
doi:
10.1002/pros.20117.
PMID15389810.
S2CID1398615.
Lin YC, You L, Xu Z, et al. (2006). "Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines". Biochem. Biophys. Res. Commun. 341 (2): 635–40.
doi:
10.1016/j.bbrc.2005.12.220.
PMID16427602.
Urakami S, Shiina H, Enokida H, et al. (2006). "Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway". Clin. Cancer Res. 12 (2): 383–91.
doi:
10.1158/1078-0432.CCR-05-1344.
PMID16428476.
S2CID22202251.
Liepinsh E, Bányai L, Patthy L, Otting G (2006). "NMR structure of the WIF domain of the human Wnt-inhibitory factor-1". J. Mol. Biol. 357 (3): 942–50.
doi:
10.1016/j.jmb.2006.01.047.
PMID16476441.
Batra S, Shi Y, Kuchenbecker KM, et al. (2006). "Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma". Biochem. Biophys. Res. Commun. 342 (4): 1228–32.
doi:
10.1016/j.bbrc.2006.02.084.
PMID16516163.
Queimado L, Lopes CS, Reis AM (2007). "WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors". Genes Chromosomes Cancer. 46 (3): 215–25.
doi:
10.1002/gcc.20402.
PMID17171686.
S2CID34184943.
Wnt inhibitory factor 1 is a
protein that in humans is encoded by the WIF1gene.[5] WIF1 is a
lipid-binding protein that binds to
Wnt proteins and prevents them from triggering signalling.[6][7][8]
Function
WNT proteins are extracellular signaling molecules involved in the control of
embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in
mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.[5]
Reguart N, He B, Xu Z, et al. (2004). "Cloning and characterization of the promoter of human Wnt inhibitory factor-1". Biochem. Biophys. Res. Commun. 323 (1): 229–34.
doi:
10.1016/j.bbrc.2004.08.075.
PMID15351726.
Esufali S, Bapat B (2004). "Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation". Oncogene. 23 (50): 8260–71.
doi:
10.1038/sj.onc.1208007.
PMID15377999.
S2CID30877665.
Ohigashi T, Mizuno R, Nakashima J, et al. (2005). "Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells". Prostate. 62 (1): 61–8.
doi:
10.1002/pros.20117.
PMID15389810.
S2CID1398615.
Lin YC, You L, Xu Z, et al. (2006). "Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines". Biochem. Biophys. Res. Commun. 341 (2): 635–40.
doi:
10.1016/j.bbrc.2005.12.220.
PMID16427602.
Urakami S, Shiina H, Enokida H, et al. (2006). "Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway". Clin. Cancer Res. 12 (2): 383–91.
doi:
10.1158/1078-0432.CCR-05-1344.
PMID16428476.
S2CID22202251.
Liepinsh E, Bányai L, Patthy L, Otting G (2006). "NMR structure of the WIF domain of the human Wnt-inhibitory factor-1". J. Mol. Biol. 357 (3): 942–50.
doi:
10.1016/j.jmb.2006.01.047.
PMID16476441.
Batra S, Shi Y, Kuchenbecker KM, et al. (2006). "Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma". Biochem. Biophys. Res. Commun. 342 (4): 1228–32.
doi:
10.1016/j.bbrc.2006.02.084.
PMID16516163.
Queimado L, Lopes CS, Reis AM (2007). "WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors". Genes Chromosomes Cancer. 46 (3): 215–25.
doi:
10.1002/gcc.20402.
PMID17171686.
S2CID34184943.